Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Lyon - Perrache Bus Station | Florenc | CheapestFastest |
Last refresh of the prices: Yesterday at 19:35 CET.
Get from Lyon to Prague
The journey takes about 19 hours 5 minutes, and with fares starting at just £45, it presents an excellent value for a comfortable ride.
Where are the popular stops in Lyon and Prague?
Stops in Lyon
- ARue de Esplanade, 69002 Lyon, France
- C
Lyon
8 Rue de la Paix, 69700 Givors, France - D
Quai de Saoune
4 Cours de Verdun Rambaud, 69002 Lyon, France - E
Villeurbanne INSA
20 Avenue Albert Einstein, 69100 Villeurbanne, France - FLes Charrières, 69570 Dardilly, France
Stops in Prague
- AKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- BChlumecká, 198 00 Praha 20, Czech Republic
- CAviatická, 161 08, Praha 6, Czechia
- DTomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
- E
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - F300/8 Wilsonova, 110 00 Praha, Czechia
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Frequently asked questions about travelling by bus from Lyon to Prague
What's the distance between Lyon and Prague by coach?
The journey from Lyon to Prague by coach covers an approximate distance of 534 miles (861 km).
What is the best way to go from Lyon to Prague without flying?
You can choose the coach to travel this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You also have the option of utilising carpooling services.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Lyon to Prague was searched and found on 2 Dec 2025 with a price of £42To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lyon to Prague as early as possible.
You can expect to pay from £42 to £103 for a bus ticket from Lyon to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at £42, which is on 2025-12-02.
Usually BlaBlaCar Bus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
