Next departures from Lyon to Brussels on 19 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Perrache
Brussels North Train Station
Cheapest
Bus
Perrache
Brussels South (Gare du Midi)
Fastest
Bus
Aéroport LYS
Brussels North Train Station
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Bus
Aéroport LYS
Brussels South (Gare du Midi)
No tags
Next departures from Lyon to Brussels on 20 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
Cheapest
Bus
Perrache
Brussels South (Gare du Midi)
Fastest
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Next departures from Lyon to Brussels on 21 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Perrache
Brussels South (Gare du Midi)
Cheapest
Bus
Perrache
Brussels South (Gare du Midi)
Fastest
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Next departures from Lyon to Brussels on 22 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Perrache
Brussels North Train Station
Cheapest
Bus
Perrache
Brussels South (Gare du Midi)
Fastest
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Next departures from Lyon to Brussels on 23 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
Cheapest
Bus
Perrache
Brussels South (Gare du Midi)
Fastest
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Next departures from Lyon to Brussels on 24 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
CheapestFastest
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Next departures from Lyon to Brussels on 25 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Perrache
Brussels North Train Station
Cheapest
Bus
Perrache
Brussels South (Gare du Midi)
Fastest
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Last refresh of the prices: Yesterday at 00:46 CET.
Compare 3 ways to travel from Lyon to Brussels
We recommend taking the train
Among the sustainable travel choices, the train stands out as a good way to reach Brussels. The journey takes about 4 hours 13 minutes and with fares starting at just £54, it presents an excellent value for a comfortable ride.
Based on 11371 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. FlixBus ticket prices on this trip start at £25
Based on 11138 reviews, the company was rated 3.7 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. BlaBlaCar Bus ticket prices on this trip start at £21
Frequently asked questions about travelling by bus from Lyon to Brussels
What's the distance between Lyon and Brussels by coach?
The distance between Lyon and Brussels by coach is approximately 353 miles (569 km).
How can I travel from Lyon to Brussels avoiding air travel?
You have the option to select the coach for your journey on this route. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You also have the option of utilising carpooling services.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
17/11
£30
18/11
£68
Today
£29
20/11
£27
21/11
£40
22/11
£27
23/11
£32
24/11
£30
The cheapest trip from Lyon to Brussels was searched and found on 20 Nov 2025 with a price of £27
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lyon to Brussels as early as possible.
You can expect to pay from £27 to £104 for a bus ticket from Lyon to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at £27, which is on 2025-11-20.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Lyon to Brussels?
The bus is the cheapest travel choice for this destination
The cheapest trip from Lyon to Brussels was searched and found on 20 Nov 2025 with a price of £27
The bus is the cheapest travel choice for this destination
