Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Depew Station | Chicago (Union Station), IL | CheapestFastest | ||||
| Train | Depew Station | Chicago (Union Station), IL | No tags | ||||
| Train | Depew Station | Chicago (Union Station), IL | No tags |
Last refresh of the prices: Last Thursday at 1:04 PM EST.
Compare 2 ways to go from Buffalo to Chicago
Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 16 hours 40 minutes, and with fares starting at just $81, it presents an excellent value for a comfortable ride.
Where are the popular train stations and stops in Buffalo, NY and Chicago?
Chicago
- A
Union Station
225 S Canal St, Chicago, IL 60606, USA
Train companies
Based on 5663 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the WiFi. Amtrak ticket prices on this trip start at $78
Frequently asked questions about travelling from Buffalo, NY to Chicago by train
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the train ticket from Buffalo to Chicago?
The cheapest train tickets from Buffalo to Chicago start at $78. The average price for this train route is around $162. Busbud recommends booking your tickets in advance to increase your chances of getting the lowest possible price.
How long is the train ride from Buffalo to Chicago?
The average train trip from Buffalo to Chicago takes 10h 33m and covers 741 km. The quickest train gets you there in 10h 33m and is operated by Amtrak.
Which train operators serve the Buffalo to Chicago route?
Several major train operators serve this route, with 1 trains available per day.
What are the earliest and latest departure times for the train from Buffalo to Chicago?
The earliest train from Buffalo to Chicago departs at 12:39am. The latest train departs at 12:39am.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Buffalo, NY to Chicago was searched and found on Dec 24, 2025 with a price of $155To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Buffalo, NY to Chicago, as early as possible.
You can expect to pay from $155 to $2,039 for a train ticket from Buffalo, NY to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $155 which is on 2025-12-24.
