Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Tupelo (Brothers Quick Stop) | New Orleans Bus Station | Cheapest | ||||
| Bus | Tupelo (Brothers Quick Stop) | New Orleans Bus Station | Fastest | ||||
| Bus | Tupelo (Brothers Quick Stop) | New Orleans Bus Station | No tags |
Last refresh of the prices: Last Saturday at 11:14 PM CST.
Get from Tupelo to New Orleans
The journey takes about 17 hours 40 minutes, and with fares starting at just $133, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 87449 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $133
Frequently asked questions about travelling from Tupelo to New Orleans by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Tupelo to New Orleans?
The cheapest bus tickets from Tupelo to New Orleans start from $133. The average price for this route is around $245. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Tupelo to New Orleans?
The average bus travel time from Tupelo to New Orleans is 17h 40m, covering a distance of 495 km. The quickest bus can get you there in 12h 15m and is operated by Greyhound.
Which bus companies service the Tupelo to New Orleans route?
Several major bus companies operate on this route with 2 buses available per day.
What are the earliest and latest departure times for the bus from Tupelo to New Orleans?
The earliest bus departs from Tupelo to New Orleans at 5:35am. And the latest bus departs at 11:15pm.
What are the CO₂ emissions for the bus trip from Tupelo to New Orleans?
A bus trip from Tupelo to New Orleans generates an estimated 12 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tupelo to New Orleans was searched and found on Dec 25, 2025 with a price of $198To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to New Orleans, as early as possible.
You can expect to pay from $198 to $376 for a bus ticket from Tupelo to New Orleans based on the last 2 days. You can expect to find the cheapest price for the trip at $198 which is on 2025-12-25.
