Bus Tickets from Spartanburg to Indianapolis

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FriJun 20
SatJun 21
SunJun 22
MonJun 23
from US$124
TueJun 24
WedJun 25
ThuJun 26
FriJun 27

Cheap buses leaving Monday

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: June 23 at
    Departure city: Spartanburg
    Departure location: Spartanburg
    Arrival time: June 23 at
    Destination city: Indianapolis
    Destination location: Downtown Transit Center
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: June 23 at
    Departure city: Spartanburg
    Departure location: Spartanburg
    Arrival time: June 24 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 23 at
    Departure city: Spartanburg
    Departure location: Spartanburg
    Arrival time: June 24 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 23 at
    Departure city: Spartanburg
    Departure location: Spartanburg
    Arrival time: June 24 at
    Destination city: Indianapolis
    Destination location: Downtown Transit Center
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: June 23 at
    Departure city: Spartanburg
    Departure location: Spartanburg
    Arrival time: June 24 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Last Monday at 6:06 PM EDT.

Prices and availability are subject to change.

Accepted payments

  • Visa
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  • American Express
  • China Union Pay
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  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Spartanburg to Indianapolis

Bus
Average PriceUS$124 - US$159Average Duration17h 5m
16kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average PriceUS$159 - US$159Average Duration1d 2h
59kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Spartanburg to Indianapolis

Among the sustainable travel choices, the bus stands out as a good way to reach Indianapolis. The journey takes about 17 hours 5 minutes, and with fares starting at just US$124, it presents an excellent value for a comfortable ride.

7bus per day
17h 5mAverage Duration
US$124Cheapest ticket
16kgCO₂ emissions

Bus Spartanburg to Indianapolis: Trip Overview

Average Ticket PriceUS$134
Average Bus Trip Duration17h 5m
Number of daily buses7
Earliest bus departure6:05am
Distance644 km
Latest bus departure9:00pm

Spartanburg to Indianapolis Bus

Busbud helps you find a bus from Spartanburg to Indianapolis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Spartanburg to Indianapolis from the most reliable bus companies operating this trip.

Discover how much the bus trip from Spartanburg to Indianapolis will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Spartanburg - Indianapolis

  1. What is the travel distance from Spartanburg to Indianapolis?

    The distance between Spartanburg and Indianapolis is around 654 km (406 miles).

  2. What are the departure and arrival locations for buses traveling from Spartanburg to Indianapolis?

    Buses traveling this route start their trip at Super Acapulco, in Spartanburg, and end it at Greyhound Amtrak Station, in Indianapolis.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06-16
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06-17
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Today
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06-19
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06-20
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06-21
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06-22
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06-23
US$126
busbud logoThe cheapest trip from Spartanburg to Indianapolis was searched and found on Jun 23, 2025 with a price of US$126

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Spartanburg to Indianapolis, as early as possible.

You can expect to pay from US$126 to US$151 for a bus ticket from Spartanburg to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at US$126 which is on 2025-06-23.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Spartanburg and Indianapolis!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Spartanburg to Indianapolis, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Spartanburg to Indianapolis will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Spartanburg to Indianapolis.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

What's the cheapest way to go from Spartanburg to Indianapolis?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Spartanburg by bus?

Bus from Spartanburg to Indianapolis

You can also go to Indianapolis by train

Train from Spartanburg to Indianapolis

Why choose Busbud?

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