Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Terminal Sur | Penco | Cheapest | ||||
| Bus | Terminal Los Héroes | Penco | Fastest | ||||
| Bus | Terminal Sur | Penco | No tags | ||||
| Bus | Terminal Sur | Penco | No tags | ||||
| Bus | Terminal Sur | Penco | No tags |
Last refresh of the prices: Last Wednesday at 9:42 PM -03.
Get from Santiago to Penco
The journey takes about 5 hours 6 minutes, and with fares starting at just $20, it presents an excellent value for a comfortable ride.
Where are the popular stops in Santiago and Penco?
Stops in Santiago
- ATucapel Jiménez 21, 8340528 Santiago, Región Metropolitana, Chile
- BSantiago - Av Libertador Bernardo O'Higgins 3850, Santiago, Estación Central, Región Metropolitana, Chile
- C
San Borja
San Francisco de Borja 199-225, Santiago, Estación Central, Región Metropolitana, Chile - DPdte. Riesco 6391-6399, Las Condes, Región Metropolitana, Chile
- EAv. Gral. Oscar Bonilla 418, Lo Prado, Región Metropolitana, Chile
- F
Santiago
Juan Esteban Montero 5688, Las Condes, Las Condes, Región Metropolitana, Chile
Stops in Penco
- A
Terminal de Autobuses de Penco
Ruta 150 9, Penco, Región del Bío Bío, Chile
Compare bus companies
Based on 157 reviews, the company was rated 3.8 stars on Busbud. Travellers were especially satisfied with the cleanliness and the ticket access but often complained with the WiFi. Eme Bus ticket prices on this trip start at $20
Frequently asked questions about travelling from Santiago, CL to Penco by bus
What is the travel distance from Santiago to Penco?
Santiago and Penco are 429 km (266 miles) apart.
What are the departure and arrival locations for buses traveling from Santiago to Penco?
Buses departing from Terminal Los Héroes in Santiago will take you to Terminal de Autobuses de Penco in Penco.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santiago, CL to Penco was searched and found on Nov 27, 2025 with a price of $19To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to Penco, as early as possible.
You can expect to pay from $19 to $37 for a bus ticket from Santiago, CL to Penco based on the last 2 days. You can expect to find the cheapest price for the trip at $19 which is on 2025-11-27.
