Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Terminal Sur | Melipeuco | CheapestFastest | ||||
 | Bus | Terminal Sur | Melipeuco | No tags | ||||
| Bus | Terminal Sur | Melipeuco | No tags |
Last refresh of the prices: Today at 8:04 AM -03.
Get from Santiago to Melipeuco
The journey takes about 10 hours, and with fares starting at just $18, it presents an excellent value for a comfortable ride.
Where are the popular stops in Santiago and Melipeuco?
Stops in Santiago
- ASantiago - Av Libertador Bernardo O'Higgins 3850, Santiago, Estación Central, Región Metropolitana, Chile
- B
San Borja
San Francisco de Borja 199-225, Santiago, Estación Central, Región Metropolitana, Chile - CTucapel Jiménez 21, 8340528 Santiago, Región Metropolitana, Chile
- DPdte. Riesco 6391-6399, Las Condes, Región Metropolitana, Chile
- EAv. Gral. Oscar Bonilla 418, Lo Prado, Región Metropolitana, Chile
- F
Santiago
Juan Esteban Montero 5688, Las Condes, Las Condes, Región Metropolitana, Chile
Stops in Melipeuco
- A
Terminal Melipeuco
Pincheira, Melipeuco, IX Región, Chile
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Frequently asked questions about travelling from Santiago, CL to Melipeuco by bus
What is the travel distance from Santiago to Melipeuco?
The distance between Santiago and Melipeuco is approximately 613 km (380 miles).
What are the departure and arrival locations for buses traveling from Santiago to Melipeuco?
Buses departing from Terminal Sur in Santiago will take you to Terminal Melipeuco in Melipeuco.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santiago, CL to Melipeuco was searched and found on Nov 25, 2025 with a price of $16To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to Melipeuco, as early as possible.
You can expect to pay from $16 to $36 for a bus ticket from Santiago, CL to Melipeuco based on the last 2 days. You can expect to find the cheapest price for the trip at $17 which is on 2025-12-02.
Usually buses TranSantin will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
Top travelled bus routes
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