Bus Tickets from San Luis, AR to Santiago, CL

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TodayJun 14
TomorrowJun 15
MonJun 16
TueJun 17
WedJun 18
from US$61
ThuJun 19
FriJun 20
SatJun 21

Cheap buses leaving Wednesday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: June 18 at
    Departure city: San Luis
    Departure location: Ediro San Luis
    Arrival time: June 18 at
    Destination city: Santiago
    Destination location: Santiago De Chile
    Operated by: Tu EnvidiaTu Envidia
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: June 18 at
    Departure city: San Luis
    Departure location: Ediro San Luis
    Arrival time: June 18 at
    Destination city: Santiago
    Destination location: Santiago De Chile
    Operated by: Tu EnvidiaTu Envidia
    Vehicle: BusDuration:
  • Departure time: June 18 at
    Departure city: San Luis
    Departure location: Ediro San Luis
    Arrival time: June 18 at
    Destination city: Santiago
    Destination location: Santiago De Chile
    Operated by: Tu EnvidiaTu Envidia
    Vehicle: BusDuration:

Last refresh of the prices: Last Thursday at 12:56 AM -03.

Prices and availability are subject to change.

Accepted payments

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Bus San Luis to Santiago: Trip Overview

Average Ticket PriceUS$88
Average Bus Trip Duration12h 10m
Number of daily buses1
Earliest bus departure11:20am
Distance407 km

San Luis to Santiago Bus

Busbud helps you find a bus from San Luis to Santiago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from San Luis to Santiago from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Santiago from San Luis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip San Luis, AR - Santiago, CL

  1. How much does a bus ticket from San Luis to Santiago cost?

    The bus ticket price from San Luis to Santiago starts at US$88. The best way to find cheap bus tickets from San Luis to Santiago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from San Luis to Santiago?

    The average travel time between San Luis and Santiago is around 12h 10m, although the fastest bus will take about 12h 10m.This is the time it takes to travel the 394 km that separates the two cities.

  3. How many daily bus connections are there between San Luis and Santiago?

    The number of buses from San Luis to Santiago can differ depending on the day of the week. On average, there are 1 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from San Luis to Santiago by comparing and selecting the bus that fits you travel style and budget on Busbud.

  4. What are the departure and arrival stations when taking the bus from San Luis to Santiago?

    Buses travelling between San Luis and Santiago leave from Estación de Interconexión Regional de Ómnibus de San Luis or Terminal de San Luis and arrive at Terminal Sur, San Borja, Terminal Los Héroes.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06-12
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06-13
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Today
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06-15
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06-16
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06-17
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06-18
US$57
06-19
No data
busbud logoThe cheapest trip from San Luis to Santiago was searched and found on Jun 18, 2025 with a price of US$57

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis to Santiago, as early as possible.

You can expect to pay from US$57 to US$69 for a bus ticket from San Luis to Santiago based on the last 2 days. You can expect to find the cheapest price for the trip at US$57 which is on 2025-06-18.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between San Luis and Santiago!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from San Luis to Santiago, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from San Luis to Santiago.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Luis to Santiago.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to San Luis by bus?

Bus from San Luis to Santiago

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