What is the distance between San Diego and Mesa?

The distance between San Diego and Mesa is around 502 km (312 miles).

What are the departure and arrival locations for buses traveling from San Diego to Mesa?

Buses traveling this route start their trip at Mission Valley Sheraton, in San Diego, and end it at Mesa Bus Station, in Mesa.

Bus San Diego to Mesa from $106 | Refundable Tickets

Next bus departures

Next departures for San Diego to Mesa on November 27
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	7:35pm	Greyhound Bus Stop	12h 5m	8:40am	Mesa Bus Stop	Cheapest
	Bus	10:00am	Greyhound Bus Stop	8h 10m	7:10pm	Mesa Bus Stop	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	7:35am	San Diego (Old Town-FlixBus)	10h 35m	7:10pm	Mesa Bus Stop	No tags
FlixBus + Greyhound Lines, Inc.	Bus	3:55pm	San Diego (Old Town-FlixBus)	15h 45m	8:40am	Mesa Bus Stop	No tags
FlixBus + Greyhound Lines, Inc.	Bus	7:55am	UCSD Health La Jolla Station	10h 15m	7:10pm	Mesa Bus Stop	No tags

Last refresh of the prices: Yesterday at 7:04 PM PST.

Get from San Diego to Mesa

This route is served by bus only

The journey takes about 12 hours 35 minutes, and with fares starting at just $81, it presents an excellent value for a comfortable ride.

8bus per day

12h 35mAverage Duration

505 kmDistance

13kgCO₂ emissions

Where are the popular stops in San Diego and Mesa?

Stops in San Diego

A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA
B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA
C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA
D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA
E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA
F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA

Stops in Mesa

A
Mesa Bus Station
1423 S Country Club , Mesa, AZ 85210, USA

Compare bus companies

Greyhound

3.5/587,396 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Based on 87396 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $82

Greyhound San Diego Mesa recent customer reviews

I missed my bus. That's my fault. The customer support was not helpfup in scheduling a new trip.

Anthony B.

September 24, 2019

FlixBus

3.5/511,448 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about travelling from San Diego, CA, US to Mesa by bus

What is the distance between San Diego and Mesa?
The distance between San Diego and Mesa is around 502 km (312 miles).
What are the departure and arrival locations for buses traveling from San Diego to Mesa?
Buses traveling this route start their trip at Mission Valley Sheraton, in San Diego, and end it at Mesa Bus Station, in Mesa.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-24

No data

11-25

No data

Today

$109

11-27

$106

11-28

No data

11-29

No data

11-30

$117

12-01

No data

The cheapest trip from San Diego, CA, US to Mesa was searched and found on Nov 27, 2025 with a price of $106

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Mesa, as early as possible.

You can expect to pay from $106 to $158 for a bus ticket from San Diego, CA, US to Mesa based on the last 2 days. You can expect to find the cheapest price for the trip at $106 which is on 2025-11-27.