Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Pittsburgh Intermodal Station | Gateway Station | CheapestFastest | ||||
| Bus | Pittsburgh Intermodal Station | Gateway Station | No tags | ||||
 | Bus | Pittsburgh Intermodal Station | Gateway Station | No tags |
Last refresh of the prices: Yesterday at 2:26 PM EST.
Compare 2 ways to go from Pittsburgh to St. Louis
Among the sustainable travel choices, the bus stands out as a good way to reach St. Louis. The journey takes about 13 hours 35 minutes, and with fares starting at just $89, it presents an excellent value for a comfortable ride.
Where are the popular stops in Pittsburgh and St. Louis?
Stops in Pittsburgh
- A55 11th St, Pittsburgh, PA 15222, USA
- B
Sennott Square
201 S Bouquet St, Pittsburgh, PA 15213, USA
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Frequently asked questions about travelling from Pittsburgh to St. Louis by bus
What is the travel distance from Pittsburgh to St. Louis?
The distance between Pittsburgh and St. Louis is around 899 km (557 miles).
What are the departure and arrival locations for buses traveling from Pittsburgh to St. Louis?
Buses traveling this route start their trip at Intermodal Station, in Pittsburgh, and end it at Gateway Station, in St. Louis.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Pittsburgh to St. Louis was searched and found on Nov 27, 2025 with a price of $106To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to St. Louis, as early as possible.
You can expect to pay from $106 to $278 for a bus ticket from Pittsburgh to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $106 which is on 2025-11-27.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Pittsburgh to St. Louis?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
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