Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Pittsburgh Intermodal Station | Gateway Station | CheapestFastest | ||||
| Bus | Pittsburgh Intermodal Station | Gateway Station | No tags | ||||
 | Bus | Pittsburgh Intermodal Station | Gateway Station | No tags |
Last refresh of the prices: Yesterday at 18:12 EST.
Compare 2 ways to travel from Pittsburgh to St. Louis
Among the sustainable travel choices, the bus stands out as a good way to reach St. Louis. The journey takes about 13 hours 35 minutes and with fares starting at just £48, it presents an excellent value for a comfortable ride.
Where are the popular stops in Pittsburgh and St. Louis?
Stops in Pittsburgh
- A55 11th St, Pittsburgh, PA 15222, USA
- B
Sennott Square
201 S Bouquet St, Pittsburgh, PA 15213, USA
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Frequently asked questions about travelling by bus from Pittsburgh to St. Louis
How far is St. Louis from Pittsburgh by coach?
The distance between Pittsburgh and St. Louis by coach is approximately 557 miles (899 km).
Is there a way to reach St. Louis from Pittsburgh without flying?
You can choose the coach to travel this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You also have the option of utilising carpooling services.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Pittsburgh to St. Louis was searched and found on 1 Dec 2025 with a price of £48To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to St. Louis as early as possible.
You can expect to pay from £48 to £178 for a bus ticket from Pittsburgh to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at £48, which is on 2025-12-01.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Pittsburgh to St. Louis?
The bus is the cheapest travel choice for this destination
