What is the distance between Pittsburgh and Chicago?

The distance between Pittsburgh and Chicago is approximately 661 km (410 miles).

What are the departure and arrival locations for buses traveling from Pittsburgh to Chicago?

Buses departing from Intermodal Station in Pittsburgh will take you to Downtown Greyhound Station in Chicago.

Bus Pittsburgh to Chicago from $77 | Refundable Tickets

Next bus departures

Next departures for Pittsburgh to Chicago on November 18
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	7:45pm	Pittsburgh Intermodal Station	11h 25m	6:10am	Downtown Greyhound Station	Cheapest
Bus	7:45pm	Pittsburgh Intermodal Station	10h 55m	5:40am	Chicago 95Th & Dan Ryan	Fastest
Bus	10:50am	Pittsburgh Intermodal Station	13h 45m	11:35pm	Downtown Greyhound Station	No tags
Bus	6:30pm	Pittsburgh Intermodal Station	14h 20m	7:50am	537-517 W. Jackson Blvd	No tags
Bus	10:50am	Pittsburgh Intermodal Station	13h 10m	11:00pm	Chicago 95Th & Dan Ryan	No tags

Next departures for Pittsburgh to Chicago on November 19
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	7:45pm	Pittsburgh Intermodal Station	10h 55m	5:40am	Chicago 95Th & Dan Ryan	Cheapest
	Bus	12:40am	Pittsburgh Intermodal Station	10h 20m	10:00am	Downtown Greyhound Station	Fastest
	Bus	1:35am	Pittsburgh Intermodal Station	14h	2:35pm	Downtown Greyhound Station	No tags
	Bus	7:45pm	Pittsburgh Intermodal Station	11h 25m	6:10am	Downtown Greyhound Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	12:40am	Pittsburgh Intermodal Station	13h 45m	1:25pm	Chicago 95Th & Dan Ryan	No tags

Next departures for Pittsburgh to Chicago on November 20
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	8:40am	Pittsburgh Intermodal Station	14h 45m	10:25pm	Chicago 95Th & Dan Ryan	Cheapest
	Bus	12:40am	Pittsburgh Intermodal Station	10h 20m	10:00am	Downtown Greyhound Station	Fastest
	Bus	1:35am	Pittsburgh Intermodal Station	14h	2:35pm	Downtown Greyhound Station	No tags
	Bus	7:45pm	Pittsburgh Intermodal Station	11h 25m	6:10am	Downtown Greyhound Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	12:40am	Pittsburgh Intermodal Station	13h 45m	1:25pm	Chicago 95Th & Dan Ryan	No tags

Next departures for Pittsburgh to Chicago on November 21
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	7:45pm	Pittsburgh Intermodal Station	11h 25m	6:10am	Downtown Greyhound Station	Cheapest
	Bus	12:40am	Pittsburgh Intermodal Station	10h 20m	10:00am	Downtown Greyhound Station	Fastest
	Bus	1:35am	Pittsburgh Intermodal Station	14h	2:35pm	Downtown Greyhound Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	12:40am	Pittsburgh Intermodal Station	13h 45m	1:25pm	Chicago 95Th & Dan Ryan	No tags
	Bus	7:45pm	Pittsburgh Intermodal Station	10h 55m	5:40am	Chicago 95Th & Dan Ryan	No tags

Next departures for Pittsburgh to Chicago on November 22
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	7:45pm	Pittsburgh Intermodal Station	11h 25m	6:10am	Downtown Greyhound Station	Cheapest
	Bus	12:40am	Pittsburgh Intermodal Station	10h 20m	10:00am	Downtown Greyhound Station	Fastest
	Bus	1:35am	Pittsburgh Intermodal Station	14h	2:35pm	Downtown Greyhound Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	12:40am	Pittsburgh Intermodal Station	13h 45m	1:25pm	Chicago 95Th & Dan Ryan	No tags
	Bus	7:45pm	Pittsburgh Intermodal Station	10h 55m	5:40am	Chicago 95Th & Dan Ryan	No tags

Next departures for Pittsburgh to Chicago on November 23
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	7:45pm	Pittsburgh Intermodal Station	11h 25m	6:10am	Downtown Greyhound Station	Cheapest
	Bus	12:40am	Pittsburgh Intermodal Station	10h 20m	10:00am	Downtown Greyhound Station	Fastest
	Bus	1:35am	Pittsburgh Intermodal Station	14h	2:35pm	Downtown Greyhound Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	12:40am	Pittsburgh Intermodal Station	13h 45m	1:25pm	Chicago 95Th & Dan Ryan	No tags
	Bus	7:45pm	Pittsburgh Intermodal Station	10h 55m	5:40am	Chicago 95Th & Dan Ryan	No tags

Next departures for Pittsburgh to Chicago on November 24
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	7:40am	Pittsburgh Intermodal Station	13h 25m	8:05pm	Downtown Greyhound Station	Cheapest
	Bus	12:40am	Pittsburgh Intermodal Station	10h 20m	10:00am	Downtown Greyhound Station	Fastest
	Bus	1:35am	Pittsburgh Intermodal Station	14h	2:35pm	Downtown Greyhound Station	No tags
	Bus	7:45pm	Pittsburgh Intermodal Station	11h 25m	6:10am	Downtown Greyhound Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	12:40am	Pittsburgh Intermodal Station	13h 45m	1:25pm	Chicago 95Th & Dan Ryan	No tags

Next departures for Pittsburgh to Chicago on November 25
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	12:40am	Pittsburgh Intermodal Station	10h 20m	10:00am	Downtown Greyhound Station	CheapestFastest
	Bus	1:35am	Pittsburgh Intermodal Station	14h	2:35pm	Downtown Greyhound Station	No tags
	Bus	7:45pm	Pittsburgh Intermodal Station	11h 25m	6:10am	Downtown Greyhound Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	12:40am	Pittsburgh Intermodal Station	13h 45m	1:25pm	Chicago 95Th & Dan Ryan	No tags
	Bus	7:40am	Pittsburgh Intermodal Station	13h 25m	8:05pm	Downtown Greyhound Station	No tags

Last refresh of the prices: Today at 3:32 AM EST.

Compare 2 ways to go from Pittsburgh to Chicago

We recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach Chicago. The journey takes about 9 hours 46 minutes, and with fares starting at just $75, it presents an excellent value for a comfortable ride.

1train per day

9h 46mAverage Duration

660 kmDistance

60kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$80 - $316	Average Duration13h 35m	CO₂ emissions 16kg CO₂e
Train	Average Price$75 - $272	Average Duration9h 46m	CO₂ emissions 60kg CO₂e

Compare bus companies

Greyhound

3.5/587,379 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

FlixBus

3.5/511,360 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in Pittsburgh and Chicago?

Stops in Pittsburgh

A - Intermodal Station

B - Sennott Square

Stops in Chicago

A - Downtown Greyhound Station

B - Chicago O'Hare International Airport

C - Polk St & Canal St

D - Tornado Bus S Kedzie Ave

E - Cumberland CTA

F - Turimex California Ave

Frequently asked questions about travelling from Pittsburgh to Chicago by bus

What is the distance between Pittsburgh and Chicago?
The distance between Pittsburgh and Chicago is approximately 661 km (410 miles).
What are the departure and arrival locations for buses traveling from Pittsburgh to Chicago?
Buses departing from Intermodal Station in Pittsburgh will take you to Downtown Greyhound Station in Chicago.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-16

$119

11-17

$129

Today

$129

11-19

$124

11-20

$116

11-21

$126

11-22

$129

11-23

$142

The cheapest trip from Pittsburgh to Chicago was searched and found on Nov 20, 2025 with a price of $116

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to Chicago, as early as possible.

You can expect to pay from $116 to $300 for a bus ticket from Pittsburgh to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $116 which is on 2025-11-20.

Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.