Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Lake City Bus Station | Orlando Bus Station | CheapestFastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Lake City Bus Station | Orlando Bus Station | No tags |
Last refresh of the prices: Last Tuesday at 11:21 AM EST.
Get from Lake City to Orlando
The journey takes about 4 hours 29 minutes, and with fares starting at just $51, it presents an excellent value for a comfortable ride.
Where are the popular stops in Lake City and Orlando?
Stops in Lake City
- A2470 W US HWY 90, Lake City, FL 32025, USA
- B
Lake City Greyhound Bus Station
251 S MARION AVE , 32055, Florida
Stops in Orlando
- A555 N John Young Pkwy, Orlando, FL 32805
- BRedCoach Station, 1777 McCoy Road, Orlando, FL 32809
- CJet Set Express Terminal, 3718 LB Mcleod Rd., 32805 Orlando, FL,, United States
- D
Disney World
Disney's All-Star Sports Resort, 1701 West Buena Vista Dr., Orlando, FL 32830 - E
International Dr SuperTours Terminal
5419 International Dr, Orlando, FL 32819, USA - F
Seaworld Hotels
10100 International Drive , Orlando, 32821
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Frequently asked questions about travelling from Lake City to Orlando by bus
What is the travel distance from Lake City to Orlando?
Lake City and Orlando are 221 km (137 miles) apart.
What are the departure and arrival locations for buses traveling from Lake City to Orlando?
Buses departing from Lake City Bus Stop in Lake City will take you to Orlando Bus Station in Orlando.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Lake City to Orlando was searched and found on Nov 22, 2025 with a price of $55To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lake City to Orlando, as early as possible.
You can expect to pay from $55 to $76 for a bus ticket from Lake City to Orlando based on the last 2 days. You can expect to find the cheapest price for the trip at $66 which is on 2025-11-25.
