Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | La Crosse MTU Transit Center | Minneapolis | Cheapest | ||||
| Bus | La Crosse MTU Transit Center | Minneapolis (U of MN - Huron Blvd) | Fastest | ||||
Jefferson Lines + Jefferson Lines | Bus | 632 17th Street North | Minneapolis (Mall of America) | No tags | ||||
| Bus | La Crosse MTU Transit Center | MSP Airport T1 (Minneapolis International Airport) | No tags | ||||
| Bus | La Crosse MTU Transit Center | MSP Airport T1 (Minneapolis International Airport) | No tags |
Last refresh of the prices: Last Sunday at 10:56 PM CST.
Get from La Crosse to Minneapolis
The journey takes about 6 hours 5 minutes, and with fares starting at just $44, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 759 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the temperature and the seats but often complained with the WiFi. Jefferson Lines ticket prices on this trip start at $44
Jefferson Lines La Crosse Minneapolis recent customer reviews
Comfy trip. On time. Friendly and competent driver.
Melora P.
Frequently asked questions about travelling from La Crosse, WI to Minneapolis by bus
How far is La Crosse from Minneapolis?
The distance between La Crosse and Minneapolis is approximately 207 km (128 miles).
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from La Crosse, WI to Minneapolis was searched and found on Nov 19, 2025 with a price of $42To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Crosse, WI to Minneapolis, as early as possible.
You can expect to pay from $42 to $132 for a bus ticket from La Crosse, WI to Minneapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $42 which is on 2025-11-21.
