How much is the bus ticket from La Crosse to Chicago?

The cheapest bus tickets from La Crosse to Chicago start from $221. The average price for this route is around $262. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from La Crosse to Chicago?

The average bus travel time from La Crosse to Chicago is 16h 55m, covering a distance of 365 km. The quickest bus can get you there in 16h 20m and is operated by Jefferson Lines .

Which bus companies service the La Crosse to Chicago route?

Several major bus companies operate on this route with 2 buses available per day.

What are the earliest and latest departure times for the bus from La Crosse to Chicago?

The earliest bus departs from La Crosse to Chicago at 12:25pm. And the latest bus departs at 4:30pm.

What are the CO₂ emissions for the bus trip from La Crosse to Chicago?

A bus trip from La Crosse to Chicago generates an estimated 9 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.

Bus La Crosse to Chicago from $255 | Refundable Tickets

Next bus departures

Next departures for La Crosse to Chicago on January 13
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	1:25pm	314 Jay St., La Crosse	16h 20m	5:45am	Chicago (Bus Station)	CheapestFastest
	Bus	1:10pm	La Crosse (U of WI)	16h 35m	5:45am	Chicago (Bus Station)	No tags

Next departures for La Crosse to Chicago on January 14
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	1:25pm	314 Jay St., La Crosse	16h 20m	5:45am	Chicago (Bus Station)	CheapestFastest
	Bus	1:10pm	La Crosse (U of WI)	16h 35m	5:45am	Chicago (Bus Station)	No tags

Next departures for La Crosse to Chicago on January 15
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	1:25pm	314 Jay St., La Crosse	16h 20m	5:45am	Chicago (Bus Station)	CheapestFastest
	Bus	1:10pm	La Crosse (U of WI)	16h 35m	5:45am	Chicago (Bus Station)	No tags

Next departures for La Crosse to Chicago on January 16
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Jefferson Lines + Jefferson Lines	Bus	4:30pm	314 Jay St., La Crosse	13h 15m	5:45am	Chicago (Bus Station)	CheapestFastest
	Bus	1:20pm	314 Jay St., La Crosse	16h 25m	5:45am	Chicago (Bus Station)	No tags
	Bus	1:05pm	La Crosse (U of WI)	16h 40m	5:45am	Chicago (Bus Station)	No tags
Jefferson Lines + Jefferson Lines	Bus	4:15pm	La Crosse (U of WI)	13h 30m	5:45am	Chicago (Bus Station)	No tags

Next departures for La Crosse to Chicago on January 18
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	1:25pm	314 Jay St., La Crosse	16h 20m	5:45am	Chicago (Bus Station)	CheapestFastest
	Bus	1:10pm	La Crosse (U of WI)	16h 35m	5:45am	Chicago (Bus Station)	No tags

Next departures for La Crosse to Chicago on January 19
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Jefferson Lines + Jefferson Lines	Bus	4:30pm	314 Jay St., La Crosse	13h 15m	5:45am	Chicago (Bus Station)	CheapestFastest
	Bus	1:20pm	314 Jay St., La Crosse	16h 25m	5:45am	Chicago (Bus Station)	No tags
Jefferson Lines + Jefferson Lines	Bus	4:15pm	La Crosse (U of WI)	13h 30m	5:45am	Chicago (Bus Station)	No tags
	Bus	1:05pm	La Crosse (U of WI)	16h 40m	5:45am	Chicago (Bus Station)	No tags

Last refresh of the prices: Yesterday at 11:11 AM CST.

Compare 2 ways to go from La Crosse to Chicago

We recommend taking the train

Among the sustainable travel choices, the Train stands out as a good way to reach Chicago. The journey takes about 5 hours 8 minutes, and with fares starting at just $48, it presents an excellent value for a comfortable ride.

4train per day

5h 8mAverage Duration

366 kmDistance

33kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$221 - $288	Average Duration16h 55m	CO₂ emissions 9kg CO₂e
Train	Average Price$48 - $338	Average Duration5h 8m	CO₂ emissions 33kg CO₂e

Compare bus companies

Jefferson Lines

4/5764 reviews

Staff4

Timeliness3.6

Cleanliness4.3

Wifi2.3

Based on 764 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Jefferson Lines ticket prices on this trip start at $262

US bus companies:FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about travelling from La Crosse, WI to Chicago by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from La Crosse to Chicago?
The cheapest bus tickets from La Crosse to Chicago start from $221. The average price for this route is around $262. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from La Crosse to Chicago?
The average bus travel time from La Crosse to Chicago is 16h 55m, covering a distance of 365 km. The quickest bus can get you there in 16h 20m and is operated by Jefferson Lines.
Which bus companies service the La Crosse to Chicago route?
Several major bus companies operate on this route with 2 buses available per day.
What are the earliest and latest departure times for the bus from La Crosse to Chicago?
The earliest bus departs from La Crosse to Chicago at 12:25pm. And the latest bus departs at 4:30pm.
What are the CO₂ emissions for the bus trip from La Crosse to Chicago?
A bus trip from La Crosse to Chicago generates an estimated 9 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

01-10

$255

01-11

$255

Today

$255

01-13

$255

01-14

$255

01-15

$255

01-16

$255

01-17

No data

The cheapest trip from La Crosse, WI to Chicago was searched and found on Jan 10, 2026 with a price of $255

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Crosse, WI to Chicago, as early as possible.

You can expect to pay from $255 to $255 for a bus ticket from La Crosse, WI to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $255 which is on 2026-01-13.