Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Bus station | Orlando Bus Station | CheapestFastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Bus station | Orlando Bus Station | No tags | ||||
 | Bus | Bus station | Orlando Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Bus station | Orlando Bus Station | No tags | ||||
| Bus | Bus station | Orlando Bus Station | No tags |
Last refresh of the prices: Yesterday at 6:58 AM EST.
Compare 2 ways to go from Florence to Orlando
Among the sustainable travel choices, the train stands out as a good way to reach Orlando. The journey takes about 9 hours 46 minutes, and with fares starting at just $92, it presents an excellent value for a comfortable ride.
Where are the popular stops in Florence and Orlando?
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Stops in Orlando
- A555 N John Young Pkwy, Orlando, FL 32805
- BRedCoach Station, 1777 McCoy Road, Orlando, FL 32809
- CJet Set Express Terminal, 3718 LB Mcleod Rd., 32805 Orlando, FL,, United States
- D
Disney World
Disney's All-Star Sports Resort, 1701 West Buena Vista Dr., Orlando, FL 32830 - E
International Dr SuperTours Terminal
5419 International Dr, Orlando, FL 32819, USA - F
Seaworld Hotels
10100 International Drive , Orlando, 32821
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Frequently asked questions about travelling from Florence, SC, US to Orlando by bus
What is the travel distance from Florence to Orlando?
It's about 653 km (405 miles) from Florence to Orlando.
What are the departure and arrival locations for buses traveling from Florence to Orlando?
Buses traveling this route start their trip at Florence Bus Station, in Florence, and end it at Orlando Bus Station, in Orlando.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Florence, SC, US to Orlando was searched and found on Nov 27, 2025 with a price of $122To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Orlando, as early as possible.
You can expect to pay from $122 to $343 for a bus ticket from Florence, SC, US to Orlando based on the last 2 days. You can expect to find the cheapest price for the trip at $122 which is on 2025-11-27.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
