What is the distance between Florence and Greenville?

It's about 263 km (163 miles) from Florence to Greenville.

What are the departure and arrival locations for buses traveling from Florence to Greenville?

Buses departing from Florence Bus Station in Florence will take you to Guadalajara Supermarket Bus Stop in Greenville.

Bus Florence to Greenville from $115 | Refundable Tickets

Previously seen trips

Next departures for Florence to Greenville on November 26
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	11:59pm	Florence, SC	13h 21m	1:20pm	1116 Woodruff Rd	No tags
Greyhound + FlixBus	Bus	5:35am	Florence, SC	16h 35m	10:10pm	1116 Woodruff Rd	No tags
	Bus	11:59pm	Florence, SC	12h 51m	12:50pm	1116 Woodruff Rd	No tags
Greyhound + FlixBus	Bus	5:35am	Florence, SC	16h 35m	10:10pm	1116 Woodruff Rd	No tags
	Bus	11:59pm	Florence, SC	12h 51m	12:50pm	1116 Woodruff Rd	No tags

Compare 2 ways to go from Florence to Greenville

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 5 hours 55 minutes, and with fares starting at just $115, it presents an excellent value for a comfortable ride.

2bus per day

5h 55mAverage Duration

244 kmDistance

6kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$115 - $268	Average Duration5h 55m	CO₂ emissions 6kg CO₂e
Train	Average Price$187 - $611	Average Duration18h 30m	CO₂ emissions 23kg CO₂e

Where are the popular stops in Florence and Greenville?

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Stops in Greenville

A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611
B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607

Compare bus companies

FlixBus

3.5/511,447 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Based on 11447 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. FlixBus ticket prices on this trip start at $115

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about travelling from Florence, SC, US to Greenville, SC by bus

What is the distance between Florence and Greenville?
It's about 263 km (163 miles) from Florence to Greenville.
What are the departure and arrival locations for buses traveling from Florence to Greenville?
Buses departing from Florence Bus Station in Florence will take you to Guadalajara Supermarket Bus Stop in Greenville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-24

$249

11-25

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Today

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11-27

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11-28

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11-29

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11-30

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12-01

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The cheapest trip from Florence, SC, US to Greenville, SC was searched and found on Nov 24, 2025 with a price of $249

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Greenville, SC, as early as possible.