Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Des Moines | Downtown Greyhound Station | CheapestFastest | ||||
| Bus | Des Moines | Downtown Greyhound Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Des Moines | Chicago 95Th & Dan Ryan | No tags | ||||
| Bus | Des Moines | Downtown Greyhound Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Des Moines | Chicago 95Th & Dan Ryan | No tags |
Last refresh of the prices: Last Thursday at 12:37 AM CST.
Get from Des Moines to Chicago
The journey takes about 8 hours 45 minutes, and with fares starting at just $64, it presents an excellent value for a comfortable ride.
Where are the popular stops in Des Moines and Chicago?
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
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Frequently asked questions about travelling from Des Moines to Chicago by bus
What is the distance between Des Moines and Chicago?
Des Moines and Chicago are 496 km (308 miles) apart.
What are the departure and arrival locations for buses traveling from Des Moines to Chicago?
Buses departing from Jefferson/Trailways Depot in Des Moines will take you to Downtown Greyhound Station in Chicago.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Des Moines to Chicago was searched and found on Nov 27, 2025 with a price of $68To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Chicago, as early as possible.
You can expect to pay from $68 to $226 for a bus ticket from Des Moines to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $68 which is on 2025-11-27.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
