Next departures for Chicago to Jefferson City on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Chicago 95Th & Dan Ryan
Jefferson City
CheapestFastest
Bus
Downtown Greyhound Station
Jefferson City
No tags
Bus
537-517 W. Jackson Blvd
Jefferson City
No tags
Next departures for Chicago to Jefferson City on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Jefferson City
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Jefferson City
Fastest
Bus
Downtown Greyhound Station
Jefferson City
No tags
Bus
537-517 W. Jackson Blvd
Jefferson City
No tags
Bus
Chicago 95Th & Dan Ryan
Jefferson City
No tags
Next departures for Chicago to Jefferson City on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Chicago 95Th & Dan Ryan
Jefferson City
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Jefferson City
Fastest
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Jefferson City
No tags
Bus
Downtown Greyhound Station
Jefferson City
No tags
Bus
537-517 W. Jackson Blvd
Jefferson City
No tags
Next departures for Chicago to Jefferson City on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Jefferson City
CheapestFastest
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Jefferson City
No tags
Bus
Downtown Greyhound Station
Jefferson City
No tags
Bus
537-517 W. Jackson Blvd
Jefferson City
No tags
Bus
Chicago 95Th & Dan Ryan
Jefferson City
No tags
Next departures for Chicago to Jefferson City on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Chicago 95Th & Dan Ryan
Jefferson City
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Jefferson City
Fastest
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Jefferson City
No tags
Bus
Downtown Greyhound Station
Jefferson City
No tags
Bus
537-517 W. Jackson Blvd
Jefferson City
No tags
Next departures for Chicago to Jefferson City on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Jefferson City
CheapestFastest
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Jefferson City
No tags
Bus
Downtown Greyhound Station
Jefferson City
No tags
Bus
537-517 W. Jackson Blvd
Jefferson City
No tags
Bus
Chicago 95Th & Dan Ryan
Jefferson City
No tags
Next departures for Chicago to Jefferson City on November 29
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Jefferson City
CheapestFastest
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Jefferson City
No tags
Bus
Downtown Greyhound Station
Jefferson City
No tags
Bus
537-517 W. Jackson Blvd
Jefferson City
No tags
Bus
Chicago 95Th & Dan Ryan
Jefferson City
No tags
Next departures for Chicago to Jefferson City on November 30
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Jefferson City
CheapestFastest
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Jefferson City
No tags
Bus
Downtown Greyhound Station
Jefferson City
No tags
Bus
537-517 W. Jackson Blvd
Jefferson City
No tags
Bus
Chicago 95Th & Dan Ryan
Jefferson City
No tags
Last refresh of the prices: Yesterday at 6:23 PM CST.
Compare 2 ways to go from Chicago to Jefferson City
We recommend taking the train
Among the sustainable travel choices, the train stands out as a good way to reach Jefferson City. The journey takes about 7 hours 46 minutes, and with fares starting at just $71, it presents an excellent value for a comfortable ride.
Based on 87391 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $74
Based on 11413 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. FlixBus ticket prices on this trip start at $97
Frequently asked questions about travelling from Chicago to Jefferson City, MO by bus
What is the travel distance from Chicago to Jefferson City?
The distance between Chicago and Jefferson City is approximately 531 km (329 miles).
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11-21
$141
11-22
$137
Today
$165
11-24
$184
11-25
$173
11-26
$210
11-27
$120
11-28
$154
The cheapest trip from Chicago to Jefferson City, MO was searched and found on Nov 27, 2025 with a price of $120
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Jefferson City, MO, as early as possible.
You can expect to pay from $120 to $223 for a bus ticket from Chicago to Jefferson City, MO based on the last 2 days. You can expect to find the cheapest price for the trip at $120 which is on 2025-11-27.
The cheapest trip from Chicago to Jefferson City, MO was searched and found on Nov 27, 2025 with a price of $120
