Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Boston (South Station) | Des Moines | Cheapest | ||||
 | Bus | Boston (South Station) | Des Moines | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Brookline | Des Moines | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Brookline | Des Moines | No tags |
Last refresh of the prices: Yesterday at 2:50 PM EST.
Get from Boston to Des Moines
The journey takes about 1 day, 21 hours 45 minutes, and with fares starting at just $168, it presents an excellent value for a comfortable ride.
Where are the popular stops in Boston and Des Moines?
Stops in Boston
- A145 Dartmouth St, Boston, MA 02116, USA
- B100 Legends Way, Boston, MA 02114, USA
- C
Copley Square
115-127 St James Ave, Boston, MA 02116, USA - D
Prudential MBTA Station
220 Huntington Ave, Boston, MA 02115, USA - E
Copley MBTA Station
650 Boylston St, Boston, MA 02116, USA - F
Long Wharf
66 Long Wharf, Boston, MA 02110, USA
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
Compare bus companies
Frequently asked questions about travelling from Boston, MA, US to Des Moines by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Boston to Des Moines?
The cheapest bus tickets from Boston to Des Moines start from $168. The average price for this route is around $374. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Boston to Des Moines?
The average bus travel time from Boston to Des Moines is 1d 21h, covering a distance of 1854 km. The quickest bus can get you there in 1d 10h and is operated by Greyhound.
Which bus companies service the Boston to Des Moines route?
What are the earliest and latest departure times for the bus from Boston to Des Moines?
The earliest bus departs from Boston to Des Moines at 1:30am. And the latest bus departs at 9:50pm.
What are the CO₂ emissions for the bus trip from Boston to Des Moines?
A bus trip from Boston to Des Moines generates an estimated 46 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Boston to Des Moines?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87435 reviews.
Which bus company has the best Wi-Fi from Boston to Des Moines?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Boston to Des Moines?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Boston to Des Moines?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Boston, MA, US to Des Moines was searched and found on Dec 25, 2025 with a price of $323To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Boston, MA, US to Des Moines, as early as possible.
You can expect to pay from $323 to $512 for a bus ticket from Boston, MA, US to Des Moines based on the last 2 days. You can expect to find the cheapest price for the trip at $393 which is on 2025-12-29.
