Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Old Town San Diego | Gateway Station | No tags | |||||
| Santa Fe Depot | Gateway Station | No tags | |||||
| Santa Fe Depot | Gateway Station | No tags | |||||
| Old Town San Diego | Gateway Station | No tags | |||||
| Old Town San Diego | Gateway Station | No tags |
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Compare 2 ways to go from San Diego to St. Louis
We recommend taking the busAmong the sustainable travel choices, the bus stands out as the good way to reach St. Louis. The journey takes about 1 day, 21 hours 35 minutes and with fares starting at just $132, it presents an excellent value for a comfortable ride.
Train San Diego, CA, US to St. Louis: Trip Overview
Please note, this information is subject to change.
Train Companies
Based on 5542 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $202
San Diego to St. Louis Train
Busbud shows you the best train ticket fares and train schedules so you can easily plan and book a trip by train from San Diego to St. Louis.
We make sure you can find a train service from San Diego to St. Louis from the most reliable train companies operating this trip.
From train tickets to high-end trains trip from San Diego to St. Louis, we offer a wide range of train services to best suit your needs depending on how much your budget is.
Frequently asked questions for your trip San Diego, CA, US - St. Louis
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Diego, CA, US to St. Louis was searched and found on Oct 21, 2025 with a price of $246To save money and be sure you have the best seat, it's a good idea to buy your train tickets from San Diego, CA, US to St. Louis, as early as possible.
About Train Travel
Train Travel Tips
Do you like to go fast? With high-speed trains going faster than 300 km/h on certain routes, the time will fly by. Taking a train between San Diego and St. Louis is also a great way to travel to arrive in the city centre and save more time for your stay in St. Louis.
Regional train? High-speed train? Whichever train to St. Louis you take, you’ll help reduce the environmental impact and carbon footprint of your trip. As you watch the landscapes unfold before your eyes, you can tell yourself that with this choice, you are making sure they remain protected.
The train emits up to 30x less CO2 for a trip between San Diego and St. Louis compared to the same trip made by plane or car. A truly ecological mode of transport that will allow you to easily reduce your carbon footprint.
Tune out to the fine sounds of your best music playlist on your train trip from San Diego to St. Louis while indulging in miles on end of beautiful scenic views.
Did you know?
You can find dogs as passengers on the trains of Moscow, where there is a large number of stray dogs. Over time, the dogs have learned the inner workings of the rail system and it is not uncommon to find one traveling between the city and the suburbs.
The longest train journey in the world is between Europe and Asia. This long journey starts from Porto in Portugal and crosses the whole European continent to reach Hanoi in Vietnam in 12 days while traveling more than 17,000 km.
New York holds the record for the most platforms and track numbers in a single station. Grand Central Station in Manhattan is one of the largest rail terminals in the world with more than 44 platforms and 67 tracks to accommodate passengers.
Top Traveled Train Routes
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