Train tickets from Florence, SC, US to Boston, MA, US

Previously seen trips

Next departures for Florence to Boston on November 24
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
AmtrakTrain
Florence Station
Boston Route 128, MANo tags
AmtrakTrain
Florence Station
Back Bay StationNo tags
AmtrakTrain
Florence Station
Back Bay StationNo tags
AmtrakTrain
Florence Station
South StationNo tags
AmtrakTrain
Florence Station
Boston Route 128, MANo tags

Compare 2 ways to go from Florence to Boston

We recommend taking the train

Among the sustainable travel choices, the train stands out as the good way to reach Boston. The journey takes about 19 hours 32 minutes and with fares starting at just $142, it presents an excellent value for a comfortable ride.

5train per day
19h 32mAverage Duration
732 milesDistance
107kgCO₂ emissions
Average Price$101 - $545Average Duration1d 2h
30kg CO₂e
Average Price$142 - $663Average Duration19h 32m
107kg CO₂e

Frequently asked questions about traveling from Florence, SC, US to Boston, MA, US by train

Find cheapest prices for trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11/22
$420
11/23
$302
Today
$302
11/25
$551
11/26
$382
11/27
$280
11/28
$315
11/29
$529
busbud logoThe cheapest trip from Florence, SC, US to Boston, MA, US was searched and found on Nov 27, 2025 with a price of $280

To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Florence, SC, US to Boston, MA, US, as early as possible.

You can expect to pay from $280 to $1,845 for a train ticket from Florence, SC, US to Boston, MA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $280 which is on 2025-11-27.

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