Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Durham Station | Depew Station | CheapestFastest | |||||
| Durham Station | Depew Station | No tags | |||||
| Durham Station | Exchange Street Station | No tags | |||||
| Durham Station | Exchange Street Station | No tags |
Last refresh of the prices: Yesterday at 12:51 AM EST.
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Compare 2 ways to go from Durham to Buffalo
Among the sustainable travel choices, the bus stands out as the good way to reach Buffalo. The journey takes about 21 hours 15 minutes and with fares starting at just $105, it presents an excellent value for a comfortable ride.
Train Durham, NC, US to Buffalo, NY: Trip Overview
Please note, this information is subject to change.
Train Companies
Based on 5564 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $186
Durham to Buffalo Train
With Busbud, comparing and booking tickets for a train from Durham to Buffalo is a breeze. Browse through an extensive selection of train fares and train schedules to find the best deals.
Train service from Durham to Buffalo will be provided by the most trusted companies.
Discover how much the train trip from Durham to Buffalo will cost you. Use our filters and sorting features to find the cheapest train tickets or high-end trains.
Frequently asked questions for your trip Durham, NC, US - Buffalo, NY
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Durham, NC, US to Buffalo, NY was searched and found on Nov 5, 2025 with a price of $188To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Durham, NC, US to Buffalo, NY, as early as possible.
You can expect to pay from $188 to $464 for a train ticket from Durham, NC, US to Buffalo, NY based on the last 2 days. You can expect to find the cheapest price for the trip at $188 which is on 2025-11-05.
About Train Travel
Train Travel Tips
Taking the fastest trains allows you to travel at speeds greater than 300 km/h. Taking a trip from Durham to Buffalo is not only much quicker but more comfortable too! You can usually travel directly to the city centre and save time while you're at it.
No matter if you plan to take a regional or high-speed train to Buffalo, the planet will thank you. You’ll help to protect the beautiful landscapes that will unfold before your very eyes.
With up to 30x less CO2 emissions for your train journey between Durham and Buffalo, the train is an ecological alternative to flights or personal cars.
Make a music playlist for your train ride from Durham to Buffalo, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
Railway companies played a major role as early as 1883 in the use of time zones as we know them today.
The first high-speed train line was inaugurated in 1964, in Japan, to connect Tokyo with Osaka. It was during the Olympics that the first passengers traveled aboard the Shinkansen at a speed of 210 km / h.
The magnetic levitation train (Maglev for short) is currently the fastest train in the world. With a speed of 603 km/ h, it is closely followed by the French high-speed train (574.8 km / h) which remains in 2020, the fastest train to date
Top Traveled Train Routes
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