Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Tupelo (Brothers Quick Stop) | Louisville, KY | No tags | ||||
Greyhound + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Louisville, KY | No tags | ||||
FlixBus + Greyhound | Bus | Tupelo (Brothers Quick Stop) | Louisville, KY | No tags | ||||
| Bus | Tupelo (Brothers Quick Stop) | Louisville, KY | No tags | ||||
Greyhound + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Louisville, KY | No tags |
Get from Tupelo to Louisville
The journey takes about 16 hours 45 minutes and with fares starting at just $61, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Tupelo to Louisville by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Tupelo to Louisville?
The cheapest bus tickets from Tupelo to Louisville start from $61. The average price for this route is around $73. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Tupelo to Louisville?
The average bus trip duration from Tupelo to Louisville is 16h 45m, covering a distance of 321 miles (518 km). The quickest bus can get you there in 11h and is operated by Greyhound.
Which bus companies service the Tupelo to Louisville route?
Several major train operators operate on this route with 5 trains available per day.
What is the earliest and latest departure time for the bus from Tupelo to Louisville?
The earliest bus departs from Tupelo to Louisville at 5:35am. And the latest bus departs at 11:15pm.
What are the CO₂ emissions for the bus trip from Tupelo to Louisville?
A bus trip from Tupelo to Louisville generates an estimated 13 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
