Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Based on 5607 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $142
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Reno to San Diego, CA, US by bus
How far is Reno from San Diego?
About 493 miles (796 km) separate Reno and San Diego.
What are the departure and arrival stations when taking the bus from Reno to San Diego?
Most of the buses traveling from Reno to San Diego leave from Reno Station and arrive at Mission Valley Sheraton. These are the main pick-up and drop-off locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.
What are the best sights and things to do in San Diego?
Once in San Diego, you can start exploring the city and discover its surroundings. The top sights and things to do are La Jolla Cove, SeaWorld San Diego, Pacific Surf School, Torrey Pines Gliderport and USS Midway Museum.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/23
$125
11/24
$254
Today
$161
11/26
No data
11/27
No data
11/28
$161
11/29
$181
11/30
$241
The cheapest trip from Reno to San Diego, CA, US was searched and found on Nov 23, 2025 with a price of $125
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Reno to San Diego, CA, US, as early as possible.
You can expect to pay from $125 to $254 for a bus ticket from Reno to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $161 which is on 2025-11-28.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
The cheapest trip from Reno to San Diego, CA, US was searched and found on Nov 23, 2025 with a price of $125
