Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Pittsburgh Intermodal Station | Downtown SD (Seaport) | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Pittsburgh Intermodal Station | UCSD Health La Jolla Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Pittsburgh Intermodal Station | San Diego (Old Town-FlixBus) | No tags | ||||
 | Bus | Pittsburgh Intermodal Station | Greyhound Bus Stop | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Pittsburgh Intermodal Station | San Diego (Old Town-FlixBus) | No tags |
Last refresh of the prices: Last Tuesday at 9:15 AM EST.
Compare 2 ways to go from Pittsburgh to San Diego
Among the sustainable travel choices, the bus stands out as the good way to reach San Diego. The journey takes about 2 days, 15 hours 5 minutes and with fares starting at just $219, it presents an excellent value for a comfortable ride.
Where are the popular stops in Pittsburgh and San Diego?
Stops in Pittsburgh
- A55 11th St, Pittsburgh, PA 15222, USA
- B
Sennott Square
201 S Bouquet St, Pittsburgh, PA 15213, USA
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Pittsburgh to San Diego, CA, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Pittsburgh to San Diego?
The cheapest bus tickets from Pittsburgh to San Diego start from $219. The average price for this route is around $355. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Pittsburgh to San Diego?
The average bus trip duration from Pittsburgh to San Diego is 2d 15h, covering a distance of 2108 miles (3399 km). The quickest bus can get you there in 2d 9h and is operated by Greyhound.
Which bus companies service the Pittsburgh to San Diego route?
Several major train operators operate on this route with 11 trains available per day.
What is the earliest and latest departure time for the bus from Pittsburgh to San Diego?
The earliest bus departs from Pittsburgh to San Diego at 1:35am. And the latest bus departs at 8:00pm.
What are the CO₂ emissions for the bus trip from Pittsburgh to San Diego?
A bus trip from Pittsburgh to San Diego generates an estimated 85 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Pittsburgh to San Diego, CA, US was searched and found on Dec 28, 2025 with a price of $279To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to San Diego, CA, US, as early as possible.
You can expect to pay from $279 to $660 for a bus ticket from Pittsburgh to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $279 which is on 2025-12-28.
What's the cheapest way to go from Pittsburgh to San Diego, CA, US?
The bus is the cheapest travel choice for this destinationTop traveled bus routes
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