Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | La Crosse (U of WI) | Indianapolis | No tags | ||||
| Bus | 314 Jay St., La Crosse | Indianapolis | No tags |
Get from La Crosse to Indianapolis
The journey takes about 1 day, 5 hours 25 minutes and with fares starting at just $184, it presents an excellent value for a comfortable ride.
Compare bus companies
Founded in 1919, Jefferson Lines provides bus services across the Midwest in the US. Their buses have WiFi, USB plugs, bathrooms, reclining seats, reading lights and GPS tracking. Tickets are non-refundable, but you can change the date by paying a fee. Known for their affordable prices and convenient schedules, if you're looking to travel in the Midwest, Jefferson Lines is the way to go.
Frequently asked questions about traveling from La Crosse, WI to Indianapolis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from La Crosse to Indianapolis?
The cheapest bus tickets from La Crosse to Indianapolis start from $184. The average price for this route is around $184. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from La Crosse to Indianapolis?
The average bus trip duration from La Crosse to Indianapolis is 1d 5h, covering a distance of 383 miles (617 km). The quickest bus can get you there in 1d 5h and is operated by Jefferson Lines.
Which bus companies service the La Crosse to Indianapolis route?
Several major train operators operate on this route with 2 trains available per day.
What is the earliest and latest departure time for the bus from La Crosse to Indianapolis?
The earliest bus departs from La Crosse to Indianapolis at 1:10pm. And the latest bus departs at 1:25pm.
What are the CO₂ emissions for the bus trip from La Crosse to Indianapolis?
A bus trip from La Crosse to Indianapolis generates an estimated 15 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from La Crosse, WI to Indianapolis was searched and found on Jan 13, 2026 with a price of $179To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Crosse, WI to Indianapolis, as early as possible.
