Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Isernia | Lampugnano bus station | No tags | ||||
| Bus | Isernia | Milan (Assago M2) | No tags | ||||
| Bus | Isernia | Milan (San Donato M3) | No tags | ||||
| Bus | Isernia | Aeroporto Malpensa T2 | No tags | ||||
| Bus | Isernia | Milan (Malpensa Aeroporto Terminal 1) | No tags |
Compare 2 ways to go from Isernia to Milano
Among the sustainable travel choices, the bus stands out as the good way to reach Milano. The journey takes about 16 hours 54 minutes and with fares starting at just $58, it presents an excellent value for a comfortable ride.
| Average Price | Average Duration | CO₂ emissions | Actions | |
|---|---|---|---|---|
| Average Price$58 - $130 | Average Duration16h 54m | 15kg CO₂e | ||
Carpool | Average Price$54 - $54 | Average Duration6h 30m | 25kg CO₂e |
Where are the popular stops in Isernia and Milano?
Stops in Milano
- BPiazza I Maggio, 1, 20099 Sesto San Giovanni MI, Italy
- CVia Giulio Natta, 228, 20151 Milano, Italy
- EVia Giuseppe Impastato, 27, 20138 Milano, Italy
- F
Molino Dorino
Molino Dorino, 20151 Milano, Italy
Compare bus companies
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Isernia to Milano by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Isernia to Milano?
The cheapest bus tickets from Isernia to Milano start from $58. The average price for this route is around $75. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Isernia to Milano?
The average bus trip duration from Isernia to Milano is 16h 54m, covering a distance of 366 miles (590 km). The quickest bus can get you there in 13h and is operated by FlixBus.
Which bus companies service the Isernia to Milano route?
Several major train operators operate on this route with 10 trains available per day.
What is the earliest and latest departure time for the bus from Isernia to Milano?
The earliest bus departs from Isernia to Milano at 11:25am. And the latest bus departs at 5:01pm.
What are the CO₂ emissions for the bus trip from Isernia to Milano?
A bus trip from Isernia to Milano generates an estimated 15 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Isernia to Milano was searched and found on Jan 7, 2026 with a price of $51To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Isernia to Milano, as early as possible.
You can expect to pay from $51 to $82 for a bus ticket from Isernia to Milano based on the last 2 days. You can expect to find the cheapest price for the trip at $51 which is on 2026-01-07.
