Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Houston Bus Station | Knoxville Bus Station | CheapestFastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Downtown Gray & Smith | Knoxville Bus Station | No tags | ||||
Valley Transit + Greyhound Lines, Inc. | Bus | Hillcroft Ave & Southwest Freeway | Knoxville Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Houston Uptown/Upper Kirby | Knoxville Bus Station | No tags | ||||
Greyhound Lines Mexico + Valley Transit + Greyhound Lines, Inc. | Bus | Hillcroft Ave & Southwest Freeway | Knoxville Bus Station | No tags |
Last refresh of the prices: Yesterday at 3:47 AM CST.
Get from Houston to Knoxville
The journey takes about 1 day, 6 hours 20 minutes and with fares starting at just $123, it presents an excellent value for a comfortable ride.
Where are the popular stops in Houston and Knoxville?
Stops in Houston
- A
Hillcroft Ave & Southwest Freeway
6590 Southwest Fwy, Houston, TX 77074, USA - B2121 Main St, Houston, TX 77002
- C
Harrisburg Greyhound Station
7000 Harrisburg Blvd, Houston, TX 77011, USA - D7011 Harrisburg Blvd, Houston, TX 77011, USA
- E
Clay St & Louisiana St
600-698 Clay St, Houston, TX 77002, USA - F
Lockwood Dr & Harvey Wilson Dr
820 Lockwood Dr, Houston, TX 77002, USA
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
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Frequently asked questions about traveling from Houston, US to Knoxville, TN by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Houston to Knoxville?
The cheapest bus tickets from Houston to Knoxville start from $123. The average price for this route is around $153. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Houston to Knoxville?
The average bus trip duration from Houston to Knoxville is 1d 6h, covering a distance of 795 miles (1283 km). The quickest bus can get you there in 22h 50m and is operated by Greyhound.
Which bus companies service the Houston to Knoxville route?
Several major bus companies operate on this route with 8 buses available per day, including services from Greyhound, FlixBus, Valley Transit.
What is the earliest and latest departure time for the bus from Houston to Knoxville?
The earliest bus departs from Houston to Knoxville at 6:35am. And the latest bus departs at 10:00pm.
What are the CO₂ emissions for the bus trip from Houston to Knoxville?
A bus trip from Houston to Knoxville generates an estimated 32 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Houston to Knoxville?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87387 reviews.
Which bus company has the best Wi-Fi from Houston to Knoxville?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Houston to Knoxville?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Houston to Knoxville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Houston, US to Knoxville, TN was searched and found on Nov 27, 2025 with a price of $141To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Houston, US to Knoxville, TN, as early as possible.
You can expect to pay from $141 to $290 for a bus ticket from Houston, US to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $143 which is on 2025-12-04.
