How much is the bus ticket from Harrisburg to San Diego?

The cheapest bus tickets from Harrisburg to San Diego start from $293. The average price for this route is around $455. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Harrisburg to San Diego?

The average bus trip duration from Harrisburg to San Diego is 2d 22h, covering a distance of 2273 miles (3666 km). The quickest bus can get you there in 2d 18h and is operated by Greyhound .

Which bus companies service the Harrisburg to San Diego route?

Several major train operators operate on this route with 9 trains available per day.

What is the earliest and latest departure time for the bus from Harrisburg to San Diego?

The earliest bus departs from Harrisburg to San Diego at 2:30am. And the latest bus departs at 9:10pm.

What are the CO₂ emissions for the bus trip from Harrisburg to San Diego?

A bus trip from Harrisburg to San Diego generates an estimated 92 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

Bus Harrisburg to San Diego from $373 | Refundable Tickets

Next bus departures

Next departures for Harrisburg to San Diego on December 29
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	9:10pm	Harrisburg Bus Station	3d 4h	10:15pm	Downtown SD (Seaport)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	9:10pm	Harrisburg Bus Station	2d 23h	5:35pm	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	9:10pm	Harrisburg Bus Station	3d	6:10pm	San Diego (Old Town-FlixBus)	No tags

Next departures for Harrisburg to San Diego on December 30
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	9:10pm	Harrisburg Bus Station	3d 4h	10:15pm	Downtown SD (Seaport)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	2:30am	Harrisburg Bus Station	2d 18h	5:35pm	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	2:30am	Harrisburg Bus Station	2d 18h	6:10pm	San Diego (Old Town-FlixBus)	No tags
	Bus	2:30am	Harrisburg Bus Station	3d	11:50pm	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	8:15pm	Harrisburg Bus Station	2d 20h	2:10pm	San Diego (Old Town-FlixBus)	No tags

Next departures for Harrisburg to San Diego on December 31
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	2:30am	Harrisburg Bus Station	2d 22h	10:15pm	Downtown SD (Seaport)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	2:30am	Harrisburg Bus Station	2d 18h	5:35pm	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	2:30am	Harrisburg Bus Station	2d 18h	6:10pm	San Diego (Old Town-FlixBus)	No tags
	Bus	2:30am	Harrisburg Bus Station	2d 18h	5:45pm	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	8:15pm	Harrisburg Bus Station	2d 20h	2:10pm	San Diego (Old Town-FlixBus)	No tags

Next departures for Harrisburg to San Diego on January 1
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	8:15pm	Harrisburg Bus Station	2d 20h	1:40pm	UCSD Health La Jolla Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	2:30am	Harrisburg Bus Station	2d 18h	5:35pm	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	2:30am	Harrisburg Bus Station	2d 18h	6:10pm	San Diego (Old Town-FlixBus)	No tags
	Bus	2:30am	Harrisburg Bus Station	2d 18h	5:45pm	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	8:15pm	Harrisburg Bus Station	2d 20h	2:10pm	San Diego (Old Town-FlixBus)	No tags

Next departures for Harrisburg to San Diego on January 2
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	8:15pm	Harrisburg Bus Station	2d 20h	2:10pm	San Diego (Old Town-FlixBus)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	2:30am	Harrisburg Bus Station	2d 18h	5:35pm	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	2:30am	Harrisburg Bus Station	2d 18h	6:10pm	San Diego (Old Town-FlixBus)	No tags
	Bus	2:30am	Harrisburg Bus Station	2d 18h	5:45pm	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	9:10pm	Harrisburg Bus Station	3d	6:10pm	San Diego (Old Town-FlixBus)	No tags

Next departures for Harrisburg to San Diego on January 3
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	8:15pm	Harrisburg Bus Station	2d 23h	4:25pm	San Diego (Old Town-FlixBus)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	2:30am	Harrisburg Bus Station	2d 18h	5:35pm	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	2:30am	Harrisburg Bus Station	2d 18h	6:10pm	San Diego (Old Town-FlixBus)	No tags
	Bus	2:30am	Harrisburg Bus Station	2d 18h	5:45pm	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	9:10pm	Harrisburg Bus Station	3d	6:10pm	San Diego (Old Town-FlixBus)	No tags

Last refresh of the prices: Last Wednesday at 10:26 PM EST.

Compare 2 ways to go from Harrisburg to San Diego

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach San Diego. The journey takes about 2 days, 22 hours 45 minutes and with fares starting at just $293, it presents an excellent value for a comfortable ride.

9bus per day

2d 22hAverage Duration

2273 milesDistance

92kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$293 - $799	Average Duration2d 22h	CO₂ emissions 92kg CO₂e
Train	Average Price$1,376 - $1,377	Average Duration3d 1h	CO₂ emissions 334kg CO₂e

Where are the popular stops in Harrisburg and San Diego?

Stops in Harrisburg

A
Harrisburg Bieber Greyhound Station
411 Market St, Harrisburg, PA 17101

Stops in San Diego

A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA
B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA
C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA
D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA
E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA
F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA

Compare bus companies

Greyhound

3.5/587,462 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from Harrisburg to San Diego, CA, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Harrisburg to San Diego?
The cheapest bus tickets from Harrisburg to San Diego start from $293. The average price for this route is around $455. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Harrisburg to San Diego?
The average bus trip duration from Harrisburg to San Diego is 2d 22h, covering a distance of 2273 miles (3666 km). The quickest bus can get you there in 2d 18h and is operated by Greyhound.
Which bus companies service the Harrisburg to San Diego route?
Several major train operators operate on this route with 9 trains available per day.
What is the earliest and latest departure time for the bus from Harrisburg to San Diego?
The earliest bus departs from Harrisburg to San Diego at 2:30am. And the latest bus departs at 9:10pm.
What are the CO₂ emissions for the bus trip from Harrisburg to San Diego?
A bus trip from Harrisburg to San Diego generates an estimated 92 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

12/27

$449

12/28

No data

Today

$463

12/30

$409

12/31

$373

The cheapest trip from Harrisburg to San Diego, CA, US was searched and found on Dec 31, 2025 with a price of $373

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Harrisburg to San Diego, CA, US, as early as possible.

You can expect to pay from $373 to $477 for a bus ticket from Harrisburg to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $373 which is on 2025-12-31.