How far is Durham from Jacksonville?

About 422 miles (681 km) separate Durham and Jacksonville.

What are the departure and arrival stations when taking the bus from Durham to Jacksonville?

Most of the buses traveling from Durham to Jacksonville leave from Durham Greyhound Bus Station and arrive at Jacksonville Amtrak Station. These are the main pick-up and drop-off locations on this route, but you could find others that could be a better fit for your travel plans.

Bus Durham to Jacksonville from $76 | Refundable Tickets

Next bus departures

Next departures for Durham to Jacksonville on November 23
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	10:05pm	Durham Greyhound Bus Station	15h 30m	1:35pm	Jacksonville Bus Station	Cheapest
	Bus	9:15pm	Durham Greyhound Bus Station	14h 15m	11:30am	Jacksonville Bus Station	Fastest

Next departures for Durham to Jacksonville on November 24
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	4:55am	Durham Greyhound Bus Station	13h 20m	6:15pm	Jacksonville Bus Station	Cheapest
	Bus	8:30am	Durham Greyhound Bus Station	12h 55m	9:25pm	Jacksonville Bus Station	Fastest
	Bus	2:50pm	Durham Greyhound Bus Station	16h 10m	7:00am	Jacksonville Bus Station	No tags
	Bus	9:15pm	Durham Greyhound Bus Station	14h 15m	11:30am	Jacksonville Bus Station	No tags
	Bus	10:05pm	Durham Greyhound Bus Station	15h 30m	1:35pm	Jacksonville Bus Station	No tags

Next departures for Durham to Jacksonville on November 25
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	4:55am	Durham Greyhound Bus Station	13h 20m	6:15pm	Jacksonville Bus Station	Cheapest
	Bus	8:30am	Durham Greyhound Bus Station	12h 55m	9:25pm	Jacksonville Bus Station	Fastest
	Bus	2:50pm	Durham Greyhound Bus Station	16h 10m	7:00am	Jacksonville Bus Station	No tags
	Bus	9:15pm	Durham Greyhound Bus Station	14h 15m	11:30am	Jacksonville Bus Station	No tags

Last refresh of the prices: Yesterday at 12:23 AM EST.

Compare 2 ways to go from Durham to Jacksonville

We recommend taking the train

Among the sustainable travel choices, the train stands out as the good way to reach Jacksonville. The journey takes about 13 hours 31 minutes and with fares starting at just $60, it presents an excellent value for a comfortable ride.

2train per day

13h 31mAverage Duration

421 milesDistance

62kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$57 - $184	Average Duration15h 30m	CO₂ emissions 17kg CO₂e
Train	Average Price$60 - $138	Average Duration13h 31m	CO₂ emissions 62kg CO₂e

Where are the popular stops in Durham and Jacksonville?

Stops in Durham

A
Durham Greyhound Bus Station
515 W Pettigrew St , Durham, NC 27703
Visit page
B
Compare Foods Durham
2000-2004 NC-55, Durham, NC 27704, USA
C
Durham Compare Foods Durham
2000 Avondale Dr, Durham, NC 27704, USA
D
Durham, NC
E Main St at Roxboro St (WB), Durham, NC 27701, USA

Stops in Jacksonville

A
Jacksonville Amtrak Station
3570 Clifford Ln, Jacksonville, FL 32209, USA
Visit page
B
W Forsyth St
1111 W Forsyth St, Jacksonville, FL 32204, USA
C
Kings Avenue Station
1003 Kings Avenue, Jacksonville, FL 32207
D
JRTC Greyhound Bus Station
111 W. Forsyth St, Jacksonville, FL 32202, USA

Compare bus companies

FlixBus

3.5/511,413 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/587,391 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about traveling from Durham, NC, US to Jacksonville, FL by bus

How far is Durham from Jacksonville?
What are the departure and arrival stations when taking the bus from Durham to Jacksonville?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/21

$133

11/22

$130

Today

$138

11/24

$150

11/25

$145

11/26

No data

11/27

No data

11/28

No data

The cheapest trip from Durham, NC, US to Jacksonville, FL was searched and found on Nov 22, 2025 with a price of $130

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Durham, NC, US to Jacksonville, FL, as early as possible.

You can expect to pay from $130 to $242 for a bus ticket from Durham, NC, US to Jacksonville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at $145 which is on 2025-11-25.