Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Columbus (E Mound St) | Wytheville Bus Station | No tags | ||||
| Bus | Columbus (E Mound St) | Wytheville Bus Station | No tags | ||||
| Bus | Columbus (E Mound St) | Wytheville Bus Station | No tags | ||||
| Bus | Columbus (E Mound St) | Wytheville Bus Station | No tags | ||||
| Bus | Columbus (E Mound St) | Wytheville Bus Station | No tags |
Get from Columbus to Wytheville
The journey takes about 7 hours 55 minutes and with fares starting at just $79, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Columbus, OH to Wytheville by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Columbus to Wytheville?
The cheapest bus tickets from Columbus to Wytheville start from $79. The average price for this route is around $79. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Columbus to Wytheville?
The average bus trip duration from Columbus to Wytheville is 7h 55m, covering a distance of 237 miles (382 km). The quickest bus can get you there in 7h 55m and is operated by Greyhound.
Which bus companies service the Columbus to Wytheville route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the bus from Columbus to Wytheville?
The earliest bus departs from Columbus to Wytheville at 12:50am. And the latest bus departs at 12:50am.
What are the CO₂ emissions for the bus trip from Columbus to Wytheville?
A bus trip from Columbus to Wytheville generates an estimated 10 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Columbus, OH to Wytheville was searched and found on Dec 29, 2025 with a price of $71To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Columbus, OH to Wytheville, as early as possible.
You can expect to pay from $71 to $71 for a bus ticket from Columbus, OH to Wytheville based on the last 2 days. You can expect to find the cheapest price for the trip at $71 which is on 2025-12-29.
