Next departures for Buffalo to Charlotte on November 20
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Niagara Frontier Transportation Authority
Charlotte Bus Station
CheapestFastest
Bus
Niagara Frontier Transportation Authority
Charlotte (Freedom Dr)
No tags
Bus
Buffalo (BUF) Airport
Charlotte Bus Station
No tags
Bus
Buffalo (BUF) Airport
Charlotte (Freedom Dr)
No tags
Next departures for Buffalo to Charlotte on November 21
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Niagara Frontier Transportation Authority
Charlotte Bus Station
Cheapest
Bus
Buffalo (BUF) Airport
Charlotte Bus Station
Fastest
Bus
Niagara Frontier Transportation Authority
Charlotte Bus Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Niagara Frontier Transportation Authority
Charlotte Bus Station
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Niagara Frontier Transportation Authority
Charlotte Bus Station
No tags
Next departures for Buffalo to Charlotte on November 22
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Buffalo (BUF) Airport
Charlotte Bus Station
Cheapest
Bus
Buffalo (BUF) Airport
Charlotte Bus Station
Fastest
Bus
Niagara Frontier Transportation Authority
Charlotte Bus Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Niagara Frontier Transportation Authority
Charlotte Bus Station
No tags
Bus
Niagara Frontier Transportation Authority
Charlotte Bus Station
No tags
Last refresh of the prices: Today at 7:51 AM EST.
Compare 2 ways to go from Buffalo to Charlotte
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach Charlotte. The journey takes about 22 hours 2 minutes and with fares starting at just $187, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Buffalo, NY to Charlotte, NC by bus
What is the travel distance from Buffalo to Charlotte?
The distance separating Buffalo and Charlotte is 539 miles (870 km).
What are the departure and arrival stations when taking the bus from Buffalo to Charlotte?
The majority of buses traveling from Buffalo to Charlotte start their journey at Buffalo Airport and wind up at Tornado & El Expreso Bus Company. These are the main pick-up and drop-off locations on this route, but you can also find other options that could better fit your plans.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/18
No data
11/19
$203
Today
$210
11/21
$188
11/22
$159
11/23
$158
11/24
$204
11/25
$327
The cheapest trip from Buffalo, NY to Charlotte, NC was searched and found on Nov 23, 2025 with a price of $158
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Buffalo, NY to Charlotte, NC, as early as possible.
You can expect to pay from $158 to $420 for a bus ticket from Buffalo, NY to Charlotte, NC based on the last 2 days. You can expect to find the cheapest price for the trip at $158 which is on 2025-11-23.
What's the cheapest way to go from Buffalo, NY to Charlotte, NC?
The bus is the cheapest travel choice for this destination