Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Syracuse bus station | Terminal Bus Palermo | Cheapest | |||||
| Syracuse bus station | Palermo Oreto Orsi | Fastest | |||||
| Syracuse bus station | Terminal Bus Palermo | No tags | |||||
 | Terminal Interbus | Terminal Bus Palermo | No tags | |||||
| Syracuse bus station | Terminal Bus Palermo | No tags |
Last refresh of the prices: Yesterday at 12:48 PM CET.
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Compare 3 ways to travel from Syracuse to Palermo
Among the sustainable travel choices, the carpool stands out as a good way to reach Palermo. The journey takes about 3 hours 10 minutes and with fares starting at just US$15, it presents an excellent value for a comfortable ride.
Bus Syracuse to Palermo: Trip Overview
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Syracuse to Palermo Bus
With Busbud, comparing and booking tickets for a bus from Syracuse to Palermo is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make it our job to connect you with the most dependable bus companies that cover bus service from Syracuse to Palermo.
From cheap bus tickets to more luxurious buses travelling from Syracuse to Palermo, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Syracuse and Palermo?
Frequently asked questions on the trip Syracuse - Palermo
How much does a bus ticket from Syracuse to Palermo cost?
The bus ticket price from Syracuse to Palermo starts at US$21. The best way to find cheap bus tickets from Syracuse to Palermo is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from Syracuse to Palermo?
The average travel time between Syracuse and Palermo is around 3h 15m, although the fastest bus will take about 3h 10m. This is the time it takes to travel the 206 km that separates the two cities.
How many daily bus connections are there between Syracuse and Palermo?
The number of buses from Syracuse to Palermo can differ depending on the day of the week. On average, there are 7 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Syracuse to Palermo by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from Syracuse to Palermo?
When taking the bus from Syracuse to Palermo, you can travel comfortably and safely with Interbus Italy, FlixBus.
What are the departure and arrival stations when taking the bus from Syracuse to Palermo?
Buses travelling between Syracuse and Palermo leave from Fermata dell'autobus Siracusa or Siracusa and arrive at Terminal Bus Palermo, Palermo Airport, Piazza Cairoli.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Syracuse to Palermo was searched and found on 02 Nov 2025 with a price of US$18To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse to Palermo as early as possible.
You can expect to pay from US$18 to US$42 for a bus ticket from Syracuse to Palermo based on the last 2 days. You can expect to find the cheapest price for the trip at US$18, which is on 2025-11-02.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from Syracuse to Palermo.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Syracuse to Palermo.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Syracuse to Palermo that are otherwise impossible to come by with a plane.
Make a music playlist for your bus ride from Syracuse to Palermo, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
What's the cheapest way to go from Syracuse to Palermo?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
Why choose Busbud?
The Best Way To Book Bus and Train Tickets
Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
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Popular Buses Connecting Syracuse
Buses Leaving from Syracuse
- Bus from Syracuse to Florence
- Coach Syracuse - Taormina
- Bus Syracuse - Catania
- Bus from Syracuse to Paris
- Coach Syracuse - Palermo
- Bus Syracuse - Noto
- Bus from Syracuse to Giardini Naxos
- Coach Syracuse - Cassibile
- Bus Syracuse - San Giovanni Rotondo
- Bus from Syracuse to Lecce
- Coach Syracuse - Letojanni
- Bus Syracuse - Naples
- Bus from Syracuse to Prato
- Coach Syracuse - Avezzano
- Bus Syracuse - Pachino
Buses Going to Syracuse
- Bus from Noto to Syracuse
- Coach Palermo - Syracuse
- Bus Paris - Syracuse
- Bus from Taormina to Syracuse
- Coach Pachino - Syracuse
- Bus Giardini Naxos - Syracuse
- Bus from Florence to Syracuse
- Coach Naples - Syracuse
- Bus Rosolini - Syracuse
- Bus from Cesena to Syracuse
- Coach Lanciano - Syracuse
- Bus Senigallia - Syracuse
- Bus from Mantua to Syracuse
- Coach Trento - Syracuse
- Bus Gioia Tauro - Syracuse
Popular Buses Connecting Palermo
Buses Leaving from Palermo
- Bus from Palermo to Frosinone
- Coach Palermo - Porto
- Bus Palermo - Modena
- Bus from Palermo to Maglie
- Coach Palermo - Catania
- Bus Palermo - Trapani
- Bus from Palermo to Barletta
- Coach Palermo - Petrosino
- Bus Palermo - Parma
- Bus from Palermo to Marina di Pietrapaola
- Coach Palermo - Milano
- Bus Palermo - Campobasso
- Bus from Palermo to Florence
- Coach Palermo - Cremona
- Bus Palermo - Porto Sant'Elpidio
Buses Going to Palermo
- Bus from Frosinone to Palermo
- Coach Bari - Palermo
- Bus Cosenza - Palermo
- Bus from Modena to Palermo
- Coach Outlet - Palermo
- Bus Catania - Palermo
- Bus from San Benedetto del Tronto to Palermo
- Coach Gallipoli - Palermo
- Bus Lecce - Palermo
- Bus from Alessandria to Palermo
- Coach Stazione di Mandatoriccio - Palermo
- Bus Pistoia - Palermo
- Bus from Perugia to Palermo
- Coach Giulianova - Palermo
- Bus Pordenone - Palermo