Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Gateway Station | Depew Station | Cheapest | ||||
| Train | Gateway Station | Depew Station | Fastest | ||||
| Train | Gateway Station | Depew Station | No tags | ||||
| Train | Gateway Station | Depew Station | No tags | ||||
| Train | Gateway Station | Depew Station | No tags |
Last refresh of the prices: Last Thursday at 20:47 CST.
Compare 2 ways to travel from St. Louis to Buffalo
Among the sustainable travel choices, the bus stands out as a good way to reach Buffalo. The journey takes about 1 day, 8 hours 45 minutes and with fares starting at just £87, it presents an excellent value for a comfortable ride.
Where are the popular train stations and stops in St. Louis and Buffalo, NY?
Train Companies
Based on 5667 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the Wi-Fi. Amtrak ticket prices on this trip start at £84
Frequently asked questions about travelling from St. Louis to Buffalo, NY by train
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much does a train ticket cost from St. Louis to Buffalo?
The cheapest train tickets from St. Louis to Buffalo start from £84. The average price for this train route is around £223. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the train journey from St. Louis to Buffalo?
The average train journey time from St. Louis to Buffalo is 23h 43m, covering a distance of 668 miles. The fastest train gets you there in 16h 58m and is operated by Amtrak.
Which train operators serve the St. Louis to Buffalo route?
Several major train operators run on this route with 1 trains available per day.
What are the earliest and latest departure times for the train from St. Louis to Buffalo?
The earliest train from St. Louis to Buffalo departs at 08:10. And the latest train departs at 14:55.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to Buffalo, NY was searched and found on 24 Dec 2025 with a price of £141To save money and be sure you have the best seat, it's a good idea to buy your train tickets from St. Louis to Buffalo, NY as early as possible.
You can expect to pay from £141 to £1,059 for a train ticket from St. Louis to Buffalo, NY based on the last 2 days. You can expect to find the cheapest price for the trip at £141, which is on 2025-12-24.
