Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Terminal Interbus | Rome Fiumicino Airport | Cheapest | ||||
| Bus | Terminal Interbus | Rome Tiburtina Bus Station | Fastest | ||||
| Bus | Terminal Interbus | Rome Anagnina | No tags | ||||
| Bus | Terminal Interbus | Rome Fiumicino Airport | No tags | ||||
| Bus | Terminal Interbus | Aeroporto Ciampino Airport (CIA) | No tags |
Last refresh of the prices: Yesterday at 20:00 CET.
Compare 3 ways to travel from Syracuse to Rome
Among the sustainable travel choices, the bus stands out as a good way to reach Rome. The journey takes about 19 hours 50 minutes and with fares starting at just £35, it presents an excellent value for a comfortable ride.
Where are the popular stops in Syracuse and Rome?
Stops in Syracuse
- AViale Paolo Orsi, 20, 96100 Siracusa SR, Italy
- B
Siracusa
Piazzale della Stazione Centrale, 21, 96100 Siracusa SR, Italy - C
Siracusa - Terminal Bus (Stazione FS)
Viale Teocrito, 68-74, 96100 Siracusa SR, Italy
Stops in Rome
- BLargo Guido Mazzoni, 3, 00162 Roma, Italy
- D
Castro Pretorio
Viale Castro Pretorio 76, 00185 Roma, Italy - E
Roma
- F
Anagnina
Via Vincenzo Giudice, 00173 Roma RM, Italy
Compare bus companies
Based on 11422 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. FlixBus ticket prices on this trip start at £35
Frequently asked questions about travelling by bus from Syracuse to Rome
How far is Rome from Syracuse by coach?
The distance between Syracuse and Rome by coach is approximately 365 miles (588 km).
Is there a way to reach Rome from Syracuse without flying?
You can choose the coach to travel this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You might also find carpooling options to travel between the two cities.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Syracuse to Rome was searched and found on 23 Nov 2025 with a price of £41To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse to Rome as early as possible.
You can expect to pay from £41 to £98 for a bus ticket from Syracuse to Rome based on the last 2 days. You can expect to find the cheapest price for the trip at £41, which is on 2025-11-26.
