Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Terminal Interbus | Rome Tiburtina Bus Station | No tags | ||||
| Bus | Terminal Interbus | Rome Anagnina | No tags | ||||
| Bus | Terminal Interbus | Rome Anagnina | No tags | ||||
| Bus | Terminal Interbus | Rome Tiburtina Bus Station | No tags | ||||
| Bus | Terminal Interbus | Rome Fiumicino Airport | No tags |
Compare 3 ways to go from Syracuse to Rome
Among the sustainable travel choices, the carpool stands out as a good way to reach Rome. The journey takes about 8 hours 50 minutes, and with fares starting at just $85, it presents an excellent value for a comfortable ride.
Where are the popular stops in Syracuse and Rome?
Stops in Syracuse
- AViale Paolo Orsi, 20, 96100 Siracusa SR, Italy
- B
Siracusa
Piazzale della Stazione Centrale, 21, 96100 Siracusa SR, Italy - C
Siracusa - Terminal Bus (Stazione FS)
Viale Teocrito, 68-74, 96100 Siracusa SR, Italy
Stops in Rome
- BLargo Guido Mazzoni, 3, 00162 Roma, Italy
- D
Castro Pretorio
Viale Castro Pretorio 76, 00185 Roma, Italy - E
Roma
- F
Anagnina
Via Vincenzo Giudice, 00173 Roma RM, Italy
Compare bus companies
Based on 11472 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. FlixBus ticket prices on this trip start at $59
Frequently asked questions about travelling from Syracuse to Rome by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Syracuse to Rome?
The cheapest bus tickets from Syracuse to Rome start from $59. The average price for this route is around $112. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Syracuse to Rome?
The average bus travel time from Syracuse to Rome is 19h 50m, covering a distance of 580 km. The quickest bus can get you there in 14h and is operated by FlixBus.
Which bus companies service the Syracuse to Rome route?
Several major bus companies operate on this route with 4 buses available per day.
What are the earliest and latest departure times for the bus from Syracuse to Rome?
The earliest bus departs from Syracuse to Rome at 7:15am. And the latest bus departs at 5:05pm.
What are the CO₂ emissions for the bus trip from Syracuse to Rome?
A bus trip from Syracuse to Rome generates an estimated 14 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Syracuse to Rome was searched and found on Dec 1, 2025 with a price of $65To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse to Rome, as early as possible.
You can expect to pay from $65 to $180 for a bus ticket from Syracuse to Rome based on the last 2 days. You can expect to find the cheapest price for the trip at $65 which is on 2025-12-01.
