Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | PRG Airport | Südseite Hauptbahnhof | CheapestFastest | |||||
| Prague (Central Bus Station Florenc) | Südseite Hauptbahnhof | No tags | |||||
Flixbus + Flixtrain | Prague (Central Bus Station Florenc) | Karlsruhe Hbf | No tags | |||||
| Prague (Central Bus Station Florenc) | Südseite Hauptbahnhof | No tags | |||||
Flixbus + Flixtrain | Prague (Na Knížecí) | Karlsruhe Hbf | No tags |
Last refresh of the prices: Yesterday at 09:31 CET.
Compare 3 ways to travel from Prague to Karlsruhe
Among the sustainable travel choices, the carpool stands out as a good way to reach Karlsruhe. The journey takes about 5 hours and with fares starting at just £19, it presents an excellent value for a comfortable ride.
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Where are the popular stops in Prague and Karlsruhe?
Frequently asked questions about travelling by bus from Prague to Karlsruhe
What's the distance between Prague and Karlsruhe by coach?
The distance between Prague and Karlsruhe by coach is approximately 281 miles (453 km).
What is the best way to go from Prague to Karlsruhe without flying?
You have the option to select the coach for your journey on this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You might also find carpooling options to travel between the two cities.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Prague to Karlsruhe was searched and found on 19 Nov 2025 with a price of £26To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Karlsruhe as early as possible.
