Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Philadelphia, 199 Spring Garden St | Knoxville Bus Station | CheapestFastest | ||||
 | Bus | 199 Spring Garden St. | Knoxville Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Cherry Hill Mall | Knoxville Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Philadelphia (Logan Square) | Knoxville Bus Station | No tags | ||||
| Bus | Schuylkill & Walnut | Knoxville Bus Station | No tags |
Last refresh of the prices: Yesterday at 07:33 EST.
Get from Philadelphia to Knoxville
The journey takes about 22 hours, and with fares starting at just £60, it presents an excellent value for a comfortable ride.
Where are the popular stops in Philadelphia and Knoxville?
Stops in Philadelphia
- BOff of Race Street between 5th Street and, N 6th St, Philadelphia, PA 19106, USA
- C
#2842 St.Vincent St
15th St Trolley Station, Philadelphia, PA 19102, USA - D
Bus Station
1001 Filbert St, Philadelphia, PA 19107, USA - E
Island Av & Suffolk Av MBFS
3000 Island Ave, Philadelphia, PA 19153, USA - F
NRG SEPTA Station
3701 Broad St, Philadelphia, PA 19148, USA
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Frequently asked questions about travelling by bus from Philadelphia, PA to Knoxville, TN
How much does a bus ticket from Philadelphia to Knoxville cost?
The bus ticket price from Philadelphia to Knoxville starts at £60. The best way to find cheap bus tickets from Philadelphia to Knoxville is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from Philadelphia to Knoxville?
The average travel time between Philadelphia and Knoxville is around 22h, although the fastest bus will take about 16h. This is the time it takes to travel the 551 miles that separates the two cities.
How many daily bus connections are there between Philadelphia and Knoxville?
The number of buses from Philadelphia to Knoxville can differ depending on the day of the week. On average, there are 7 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Philadelphia to Knoxville by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from Philadelphia to Knoxville?
When taking the bus from Philadelphia to Knoxville, you can travel comfortably and safely with Greyhound, FlixBus.
What are the departure and arrival stations when taking the bus from Philadelphia to Knoxville?
Buses travelling between Philadelphia and Knoxville leave from Philadelphia Airport or Independence Travel Center and arrive at 100 Kirkwood St.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Philadelphia, PA to Knoxville, TN was searched and found on 29 Nov 2025 with a price of £79To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Philadelphia, PA to Knoxville, TN as early as possible.
You can expect to pay from £79 to £211 for a bus ticket from Philadelphia, PA to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at £79, which is on 2025-11-29.
