Next departures from Brussels to Lyon on 27 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels North Train Station
Perrache
Cheapest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Fastest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels Airport
Perrache
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Next departures from Brussels to Lyon on 28 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Cheapest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Fastest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels Airport
Perrache
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Next departures from Brussels to Lyon on 29 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels North Train Station
Perrache
Cheapest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Fastest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels Airport
Perrache
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Next departures from Brussels to Lyon on 30 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Cheapest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Fastest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Next departures from Brussels to Lyon on 1 December
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Cheapest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Fastest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Next departures from Brussels to Lyon on 2 December
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
CheapestFastest
Next departures from Brussels to Lyon on 3 December
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
CheapestFastest
Next departures from Brussels to Lyon on 4 December
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Cheapest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Fastest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Last refresh of the prices: Today at 13:31 CET.
Compare 3 ways to travel from Brussels to Lyon
We recommend carpooling
Among the sustainable travel choices, the carpool stands out as a good way to reach Lyon. The journey takes about 7 hours 50 minutes and with fares starting at just £43, it presents an excellent value for a comfortable ride.
Based on 11455 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. FlixBus ticket prices on this trip start at £24
Based on 11165 reviews, the company was rated 3.7 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. BlaBlaCar Bus ticket prices on this trip start at £21
Frequently asked questions about travelling by bus from Brussels to Lyon
How far is Lyon from Brussels by coach?
The journey from Brussels to Lyon by coach covers an approximate distance of 353 miles (569 km).
What is the best way to go from Brussels to Lyon without flying?
You can choose the coach to travel this route. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You might also find carpooling options to travel between the two cities.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
25/11
£33
26/11
£39
Today
£26
28/11
£34
29/11
£27
30/11
£39
01/12
£21
02/12
£30
The cheapest trip from Brussels to Lyon was searched and found on 1 Dec 2025 with a price of £21
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Brussels to Lyon as early as possible.
You can expect to pay from £21 to £100 for a bus ticket from Brussels to Lyon based on the last 2 days. You can expect to find the cheapest price for the trip at £21, which is on 2025-12-01.
What's the cheapest way to go from Brussels to Lyon?
The bus is the cheapest travel choice for this destination
The cheapest trip from Brussels to Lyon was searched and found on 1 Dec 2025 with a price of £21
The bus is the cheapest travel choice for this destination
