Next departures for Brussels to Lyon on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels North Train Station
Perrache
Cheapest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Fastest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels Airport
Perrache
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Next departures for Brussels to Lyon on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Cheapest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Fastest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels Airport
Perrache
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Next departures for Brussels to Lyon on November 29
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels North Train Station
Perrache
Cheapest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Fastest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels Airport
Perrache
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Next departures for Brussels to Lyon on November 30
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Cheapest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Fastest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Next departures for Brussels to Lyon on December 1
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Cheapest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Fastest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Next departures for Brussels to Lyon on December 2
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
CheapestFastest
Next departures for Brussels to Lyon on December 3
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
CheapestFastest
Next departures for Brussels to Lyon on December 4
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Cheapest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Fastest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Last refresh of the prices: Today at 11:31 AM CET.
Compare 3 ways to go from Brussels to Lyon
We recommend carpooling
Among the sustainable travel choices, the carpool stands out as a good way to reach Lyon. The journey takes about 7 hours 50 minutes, and with fares starting at just $79, it presents an excellent value for a comfortable ride.
Based on 11454 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. FlixBus ticket prices on this trip start at $45
Based on 11165 reviews, the company was rated 3.7 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. BlaBlaCar Bus ticket prices on this trip start at $38
Frequently asked questions about travelling from Brussels to Lyon by bus
What is the distance between Brussels and Lyon?
It's about 569 km (353 miles) from Brussels to Lyon.
What are the departure and arrival locations for buses traveling from Brussels to Lyon?
Buses departing from Brussels South (Gare du Midi) in Brussels will take you to Lyon Airport in Lyon.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11-25
$61
11-26
$72
Today
$48
11-28
$59
11-29
$50
11-30
$72
12-01
$38
12-02
$55
The cheapest trip from Brussels to Lyon was searched and found on Dec 1, 2025 with a price of $38
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Brussels to Lyon, as early as possible.
You can expect to pay from $38 to $186 for a bus ticket from Brussels to Lyon based on the last 2 days. You can expect to find the cheapest price for the trip at $38 which is on 2025-12-01.
What's the cheapest way to go from Brussels to Lyon?
The bus is the cheapest travel choice for this destination
The cheapest trip from Brussels to Lyon was searched and found on Dec 1, 2025 with a price of $38
The bus is the cheapest travel choice for this destination
