Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Winston Salem Greyhound Bus Station | Gateway Station | No tags | ||||
| Bus | Winston Salem Greyhound Bus Station | Gateway Station | No tags | ||||
FlixBus + Greyhound | Bus | Winston Salem Greyhound Bus Station | Gateway Station | No tags | ||||
| Bus | Winston Salem Greyhound Bus Station | Gateway Station | No tags | ||||
| Bus | Winston Salem Greyhound Bus Station | Gateway Station | No tags |
Get from Winston-Salem to St. Louis
The journey takes about 23 hours 45 minutes, and with fares starting at just $243, it presents an excellent value for a comfortable ride.
Where are the popular stops in Winston-Salem and St. Louis?
Stops in Winston-Salem
- A
Winston Salem Greyhound Bus Station
100 W 5th St, Winston Salem, NC 27101 - B
E Sprague St
841 E Sprague St, Winston-Salem, NC 27107, USA - C
Winston-Salem Bus Stop
2500 Old Lexington Rd, Winston-Salem, NC 27107, USA - D
1237 Silas Creek Pkwy
1237 Silas Creek Pkwy., Winston-Salem, NC 27127 (Hong Kong King Buffet)
Compare bus companies
Based on 87493 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $243
Frequently asked questions about travelling from Winston-Salem to St. Louis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Winston-Salem to St. Louis?
The cheapest bus tickets from Winston-Salem to St. Louis start from $243. The average price for this route is around $289. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Winston-Salem to St. Louis?
The average bus travel time from Winston-Salem to St. Louis is 23h 45m, covering a distance of 924 km. The quickest bus can get you there in 22h 40m and is operated by Greyhound.
Which bus companies service the Winston-Salem to St. Louis route?
Several major bus companies operate on this route with 2 buses available per day.
What are the earliest and latest departure times for the bus from Winston-Salem to St. Louis?
The earliest bus departs from Winston-Salem to St. Louis at 10:25am. And the latest bus departs at 6:15pm.
What are the CO₂ emissions for the bus trip from Winston-Salem to St. Louis?
A bus trip from Winston-Salem to St. Louis generates an estimated 23 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Winston-Salem to St. Louis was searched and found on Jan 10, 2026 with a price of $203To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Winston-Salem to St. Louis, as early as possible.
