Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | SANTANDER | LYON | Cheapest | ||||
| Bus | SANTANDER | LYON | Fastest |
Last refresh of the prices: Today at 11:34 AM CET.
Compare 2 ways to go from Santander to Lyon
Among the sustainable travel choices, the carpool stands out as a good way to reach Lyon. The journey takes about 10 hours 50 minutes, and with fares starting at just $119, it presents an excellent value for a comfortable ride.
| Average Price | Average Duration | CO₂ emissions | Actions | |
|---|---|---|---|---|
| Average Price$104 - $267 | Average Duration19h 55m | 18kg CO₂e | ||
Carpool | Average Price$119 - $119 | Average Duration10h 50m | 31kg CO₂e |
Where are the popular stops in Santander and Lyon?
Stops in Santander
- ACalle Navas de Tolosa, 2, 39002 Santander, Cantabria, Spain
- C
Av. de los Castros 43A
Av. de los Castros 43A, 39005 Santander, Cantabria, Spain - D
Calle Camarreal-Ojaiz
Calle Camarreal-Ojaiz, 52, 39011 Santander, Cantabria, Spain - E
Av. de Pontejos
Av. de Pontejos, 33A, 39005 Santander, Cantabria, Spain - F
Estación Marítima
39002 Santander, Cantabria, Spain
Stops in Lyon
- ARue de Esplanade, 69002 Lyon, France
- C
Lyon
8 Rue de la Paix, 69700 Givors, France - D
Quai de Saoune
4 Cours de Verdun Rambaud, 69002 Lyon, France - E
Villeurbanne INSA
20 Avenue Albert Einstein, 69100 Villeurbanne, France - FLes Charrières, 69570 Dardilly, France
Compare bus companies
Frequently asked questions about travelling from Santander to Lyon by bus
What is the distance between Santander and Lyon?
Santander and Lyon are 732 km (454 miles) apart.
What are the departure and arrival locations for buses traveling from Santander to Lyon?
Buses departing from Calle Navas de Tolosa, 2 in Santander will take you to Perrache in Lyon.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santander to Lyon was searched and found on Nov 28, 2025 with a price of $48To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santander to Lyon, as early as possible.
You can expect to pay from $48 to $197 for a bus ticket from Santander to Lyon based on the last 2 days. You can expect to find the cheapest price for the trip at $48 which is on 2025-11-28.
