Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | San Ysidro Greyhound Bus Station | Hesperia Main Street | CheapestFastest | ||||
| Bus | San Ysidro Greyhound Bus Station | Hesperia Main Street | No tags | ||||
 | Bus | San Ysidro Greyhound Bus Station | 14717 Bear Valley Rd (Carl’s Jr.) | No tags | ||||
| Bus | San Ysidro Greyhound Bus Station | 14717 Bear Valley Rd (Carl’s Jr.) | No tags | ||||
| Bus | San Ysidro Greyhound Bus Station | 14717 Bear Valley Rd (Carl’s Jr.) | No tags |
Last refresh of the prices: Yesterday at 10:11 PM PST.
Get from San Ysidro to Hesperia
This route is served by bus only
The journey takes about 4 hours 10 minutes, and with fares starting at just $123, it presents an excellent value for a comfortable ride.
5bus per day
4h 10mAverage Duration
217 kmDistance
5kgCO₂ emissions
Compare bus companies
3.5 out of 5 stars3.5/5268 reviews
3.5 out of 5 stars3.5/548 reviews
US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad
Frequently asked questions about travelling from San Ysidro, CA to Hesperia by bus
What is the distance between San Ysidro and Hesperia?
The distance between San Ysidro and Hesperia is around 211 km (131 miles).
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11-24
No data
11-25
$111
Today
$121
11-27
$121
11-28
No data
11-29
No data
11-30
No data
12-01
No data
The cheapest trip from San Ysidro, CA to Hesperia was searched and found on Nov 25, 2025 with a price of $111To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Ysidro, CA to Hesperia, as early as possible.
You can expect to pay from $111 to $131 for a bus ticket from San Ysidro, CA to Hesperia based on the last 2 days. You can expect to find the cheapest price for the trip at $121 which is on 2025-11-27.
