Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | San Francisco Bus Station | Knoxville Bus Station | No tags | ||||
FlixBus + Greyhound | Bus | 409 Townsend St, SF | Knoxville Bus Station | No tags | ||||
| Bus | San Francisco Bus Station | Knoxville Bus Station | No tags | ||||
| Bus | San Francisco Bus Station | Knoxville Bus Station | No tags | ||||
Greyhound + FlixBus | Bus | 409 Townsend St, SF | Knoxville Bus Station | No tags |
Get from San Francisco to Knoxville
The journey takes about 2 days, 20 hours 10 minutes, and with fares starting at just $322, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Francisco and Knoxville?
Stops in San Francisco
- A
Hyde/Beach (Fisherman's Wharf)
700 Beach Street, San Francisco, CA 94109, USA - B
Powell Station
25 Cyril Magnin St , San Francisco, CA 94102-2812 - C
Union Square Hilton
255 Mason St,, San Francisco, CA 94102-2114 - D
San Francisco Greyhound Station
200 Folsom St, San Francisco, CA 94105 - E
444 Townsend St.
444 Townsend St, San Francisco, CA 94107, USA
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Based on 87519 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. Greyhound ticket prices on this trip start at $322
Frequently asked questions about travelling from San Francisco, US to Knoxville, TN by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from San Francisco to Knoxville?
The cheapest bus tickets from San Francisco to Knoxville start from $322. The average price for this route is around $329. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from San Francisco to Knoxville?
The average bus travel time from San Francisco to Knoxville is 2d 20h, covering a distance of 3408 km. The quickest bus can get you there in 2d 13h and is operated by Greyhound.
Which bus companies service the San Francisco to Knoxville route?
Several major bus companies operate on this route with 5 buses available per day.
What are the earliest and latest departure times for the bus from San Francisco to Knoxville?
The earliest bus departs from San Francisco to Knoxville at 6:30am. And the latest bus departs at 10:40pm.
What are the CO₂ emissions for the bus trip from San Francisco to Knoxville?
A bus trip from San Francisco to Knoxville generates an estimated 85 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
