Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Port St. Lucie (Park & Ride) | Ft Myers Bus Station | CheapestFastest |
Last refresh of the prices: Yesterday at 7:51 AM EST.
Get from Port Saint Lucie to Fort Myers
The journey takes about 11 hours 5 minutes, and with fares starting at just $53, it presents an excellent value for a comfortable ride.
Where are the popular stops in Port Saint Lucie and Fort Myers?
Stops in Port Saint Lucie
- A
Port St Lucie Mobil Gas Bus Stop
1820 Sw Fountainview Blvd, Port Saint Lucie, FL 34986 - B
Port Saint Lucie - Wendys
1790 SW St Lucie W Blvd, Port St Lucie, FL 34986 - C
Port Saint LucieService Plaza
Florida's Turnpike, Milepost 144, Port St Lucie, FL 34984, USA - D
Port Saint Lucie Bus Stop
2198 SW Gatlin Blvd. Port St. Lucie, FL 34953
Stops in Fort Myers
- A
Daniels Pkwy & I-75
13600 Indian Paint Ln (McDonald's on Daniels Pwy and I-75), Fort Myers, FL 33912 - B
Colonial Blvd & I-75
Walmart, 4770 Colonial Blvd, Fort Myers, FL 33966 - C
Rosa Parks
2250 Widman Way, Fort Myers, FL 33901
Compare bus companies
Based on 11413 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. FlixBus ticket prices on this trip start at $53
Frequently asked questions about travelling from Port Saint Lucie to Fort Myers by bus
How far is Port Saint Lucie from Fort Myers?
Port Saint Lucie and Fort Myers are 166 km (103 miles) apart.
What are the departure and arrival locations for buses traveling from Port Saint Lucie to Fort Myers?
Buses departing from Port St Lucie Mobil Gas Bus Stop in Port Saint Lucie will take you to Daniels Pkwy & I-75 in Fort Myers.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Port Saint Lucie to Fort Myers was searched and found on Nov 24, 2025 with a price of $109To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Port Saint Lucie to Fort Myers, as early as possible.
You can expect to pay from $109 to $168 for a bus ticket from Port Saint Lucie to Fort Myers based on the last 2 days. You can expect to find the cheapest price for the trip at $109 which is on 2025-11-24.
