Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Schuylkill & Walnut | Des Moines | Cheapest | ||||
 | Bus | 199 Spring Garden St. | Des Moines | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | 199 Spring Garden St. | Des Moines | No tags | ||||
| Bus | Schuylkill & Walnut | Des Moines | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Philadelphia, 199 Spring Garden St | Des Moines | No tags |
Last refresh of the prices: Yesterday at 8:33 PM EST.
Get from Philadelphia to Des Moines
The journey takes about 1 day, 8 hours 35 minutes, and with fares starting at just $181, it presents an excellent value for a comfortable ride.
Where are the popular stops in Philadelphia and Des Moines?
Stops in Philadelphia
- BOff of Race Street between 5th Street and, N 6th St, Philadelphia, PA 19106, USA
- C
#2842 St.Vincent St
15th St Trolley Station, Philadelphia, PA 19102, USA - D
Bus Station
1001 Filbert St, Philadelphia, PA 19107, USA - E
Island Av & Suffolk Av MBFS
3000 Island Ave, Philadelphia, PA 19153, USA - F
NRG SEPTA Station
3701 Broad St, Philadelphia, PA 19148, USA
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
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Frequently asked questions about travelling from Philadelphia, PA to Des Moines by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Philadelphia to Des Moines?
The cheapest bus tickets from Philadelphia to Des Moines start from $181. The average price for this route is around $265. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Philadelphia to Des Moines?
The average bus travel time from Philadelphia to Des Moines is 1d 8h, covering a distance of 1562 km. The quickest bus can get you there in 1d 2h and is operated by Greyhound.
Which bus companies service the Philadelphia to Des Moines route?
What are the earliest and latest departure times for the bus from Philadelphia to Des Moines?
The earliest bus departs from Philadelphia to Des Moines at 7:00am. And the latest bus departs at 10:30pm.
What are the CO₂ emissions for the bus trip from Philadelphia to Des Moines?
A bus trip from Philadelphia to Des Moines generates an estimated 39 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Philadelphia to Des Moines?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87387 reviews.
Which bus company has the best Wi-Fi from Philadelphia to Des Moines?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Philadelphia to Des Moines?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Philadelphia to Des Moines?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Philadelphia, PA to Des Moines was searched and found on Nov 26, 2025 with a price of $487To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Philadelphia, PA to Des Moines, as early as possible.
You can expect to pay from $487 to $691 for a bus ticket from Philadelphia, PA to Des Moines based on the last 2 days. You can expect to find the cheapest price for the trip at $665 which is on 2025-11-29.
