Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Paysandu - ROU | Estación Terminal de Ómnibius, Santa Fe | No tags | ||||
 | Bus | Estación Paysandú | Estación Terminal de Ómnibius, Santa Fe | No tags | ||||
| Bus | Paysandu - ROU | Estación Terminal de Ómnibius, Santa Fe | No tags | ||||
| Bus | Estación Paysandú | Estación Terminal de Ómnibius, Santa Fe | No tags | ||||
| Bus | Paysandu - ROU | Estación Terminal de Ómnibius, Santa Fe | No tags |
Get from Paysandú to Santa Fe
The journey takes about 5 hours, and with fares starting at just $109, it presents an excellent value for a comfortable ride.
Where are the popular stops in Paysandú and Santa Fe?
Stops in Paysandú
- ACerrito 1305, 60000 Paysandú, Departamento de Paysandú, Uruguay
Stops in Santa Fe
- A
Estación Terminal de Ómnibius, Santa Fe
Estación Terminal de Onmibus Belgrano 2900 , S3000GCH Santa Fe, Argentina
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Frequently asked questions about travelling from Paysandú to Santa Fe, AR by bus
What is the distance between Paysandú and Santa Fe?
Paysandú and Santa Fe are 260 km (161 miles) apart.
What are the departure and arrival locations for buses traveling from Paysandú to Santa Fe?
Buses departing from Estación Paysandú in Paysandú will take you to Estación Terminal de Ómnibius, Santa Fe in Santa Fe.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Paysandú to Santa Fe, AR was searched and found on Nov 26, 2025 with a price of $104To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Paysandú to Santa Fe, AR, as early as possible.
You can expect to pay from $104 to $169 for a bus ticket from Paysandú to Santa Fe, AR based on the last 2 days. You can expect to find the cheapest price for the trip at $129 which is on 2025-11-28.
