Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Bus Station | Wytheville Bus Station | CheapestFastest |
Last refresh of the prices: Last Saturday at 4:49 AM EST.
Get from Myrtle Beach to Wytheville
The journey takes about 15 hours, and with fares starting at just $121, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 87491 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $126
Frequently asked questions about travelling from Myrtle Beach to Wytheville by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Myrtle Beach to Wytheville?
The cheapest bus tickets from Myrtle Beach to Wytheville start from $121. The average price for this route is around $184. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Myrtle Beach to Wytheville?
The average bus travel time from Myrtle Beach to Wytheville is 15h, covering a distance of 406 km. The quickest bus can get you there in 15h and is operated by Greyhound.
Which bus companies service the Myrtle Beach to Wytheville route?
Several major bus companies operate on this route with 1 buses available per day.
What are the earliest and latest departure times for the bus from Myrtle Beach to Wytheville?
The earliest bus departs from Myrtle Beach to Wytheville at 1:55pm. And the latest bus departs at 1:55pm.
What are the CO₂ emissions for the bus trip from Myrtle Beach to Wytheville?
A bus trip from Myrtle Beach to Wytheville generates an estimated 10 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Myrtle Beach to Wytheville was searched and found on Jan 13, 2026 with a price of $123To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Myrtle Beach to Wytheville, as early as possible.
You can expect to pay from $123 to $138 for a bus ticket from Myrtle Beach to Wytheville based on the last 2 days. You can expect to find the cheapest price for the trip at $123 which is on 2026-01-13.
