Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Mesa Bus Stop | Downtown Greyhound Station | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Mesa Bus Stop | Chicago 95Th & Dan Ryan | Fastest | ||||
 | Bus | Mesa Bus Stop | 537-517 W. Jackson Blvd | No tags |
Last refresh of the prices: Last Thursday at 5:02 PM MST.
Get from Mesa to Chicago
The journey takes about 1 day, 18 hours 30 minutes, and with fares starting at just $321, it presents an excellent value for a comfortable ride.
Where are the popular stops in Mesa and Chicago?
Stops in Mesa
- A
Mesa Bus Station
1423 S Country Club , Mesa, AZ 85210, USA
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Based on 87407 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $341
Frequently asked questions about travelling from Mesa to Chicago by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Mesa to Chicago?
The cheapest bus tickets from Mesa to Chicago start from $321. The average price for this route is around $435. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Mesa to Chicago?
The average bus travel time from Mesa to Chicago is 1d 18h, covering a distance of 2320 km. The quickest bus can get you there in 1d 18h and is operated by Greyhound.
Which bus companies service the Mesa to Chicago route?
Several major bus companies operate on this route with 5 buses available per day.
What are the earliest and latest departure times for the bus from Mesa to Chicago?
The earliest bus departs from Mesa to Chicago at 8:40am. And the latest bus departs at 9:10pm.
What are the CO₂ emissions for the bus trip from Mesa to Chicago?
A bus trip from Mesa to Chicago generates an estimated 58 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mesa to Chicago was searched and found on Nov 29, 2025 with a price of $581To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mesa to Chicago, as early as possible.
